氟桂利嗪预防性治疗前庭性偏头痛眩晕发作的前瞻性随机对照研究  

A prospective randomized controlled study of flunarizine for the prophylactic treatment of vestibular migraine vertigo attacks

作　　者：李晓燕[1] 李东波[1] 陈钰 LI Xiao-yan;LI Dong-bo;CHEN Yu(Department of Otolaryngology,Xinhua Hospital Affiliated to Dalian University,Dalian 116000,China)

机构地区：[1]大连大学附属新华医院耳鼻喉科,116000

出　　处：《中国现代药物应用》2022年第13期142-145,共4页Chinese Journal of Modern Drug Application

摘　　要：目的评价氟桂利嗪预防性治疗前庭性偏头痛(VM)眩晕发作的效果和可靠性。方法40例VM患者,随机分为观察组和对照组,各20例。对照组仅在眩晕发作时口服甲磺酸倍他司汀片对症治疗,观察组在对照组的基础上加服盐酸氟桂利嗪胶囊治疗。比较两组患者临床疗效、前庭症状指数(VSI)评分、眩晕障碍量表(DHI)评分、眩晕发作总次数和总天数、不良反应发生率。结果观察组患者治疗总有效率95.00%显著高于对照组的60.00%,差异具有统计学意义(P<0.05)。观察组患者VSI评分(12.42±1.48)分、DHI评分(24.43±3.00)分均明显低于对照组的(23.93±2.72)、(42.52±5.00)分,差异具有统计学意义(P<0.05)。观察组患者眩晕发作总次数(2.25±1.23)次少于对照组的(6.48±2.18)次,发作总天数(3.82±2.51)d短于对照组的(7.84±3.36)d,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论使用氟桂利嗪可明显预防VM导致的眩晕发作,其预后治疗效果显著,而且安全可靠,故可以推广应用。Objective To evaluate the effect and reliability of flunarizine for the prophylactic treatment of vestibular migraine(VM)vertigo attacks.Methods A total of 40 cases of VM patients were randomly divided into observation group and control group,with 20 cases in each group.The control group was only given oral betahistine mesilate tablets for symptomatic treatment during vertigo attack,and the observation group was additionally given flunarizine hydrochloride capsules on the basis of the control group.The clinical efficacy,vestibular symptom index(VSI)score,dizziness handicap inventory(DHI)score,the frequency and days of vertigo attacks,and the incidence of adverse reactions were compared between the two groups.Results The total effective rate 95.00% in the observation group was significantly higher than 60.00% in the control group,and the difference was statistically significant(P<0.05).The VSI score(12.42±1.48)points and DHI score(24.43±3.00)points of the observation group were significantly lower than(23.93±2.72)and(42.52±5.00)points of the control group,and the differences were statistically significant(P<0.05).The frequency of vertigo attacks(2.25±1.23)times in the observation group was less than(6.48±2.18)times in the control group,and the total number of days of vertigo attacks(3.82±2.51)d was shorter than(7.84±3.36)d in the control group.All the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Flunarizine has significant effect in prophylactic treatment of vertigo attacks caused by VM,and it is safe and reliable,so it can be popularized and applied.

关 键 词：氟桂利嗪 前庭性偏头痛 预防性治疗 甲磺酸倍他司汀片 

分 类 号：R747.2[医药卫生—神经病学与精神病学]