经导管动脉化疗栓塞联合槐耳颗粒治疗Ⅰ期肝细胞癌患者的安全性及对预后的影响  

Safety of transcatheter arterial chemoembolization combined with huaier granules in the treatment of patients with stage Ⅰ hepatocellular carcinoma and its effect on prognosis

作　　者：张卿 熊晏[1] 汪晓凤[1] 龙黎 ZHANG Qing;XIONG Yan;WANG Xiaofeng;LONG Li(Department of Infectious Diseases,Guizhou Provincial People’s Hospital,Guiyang 550003,Guizhou,China)

机构地区：[1]贵州省人民医院感染科,贵州贵阳550003

出　　处：《癌症进展》2022年第13期1334-1337,共4页Oncology Progress

基　　金：贵州省科技支撑计划项目(黔科合支撑[2021]一般053)。

摘　　要：目的探讨经导管动脉化疗栓塞(TACE)联合槐耳颗粒治疗Ⅰ期肝细胞癌(HCC)患者的安全性及对预后的影响,并分析预后的影响因素。方法根据TACE治疗后是否口服槐耳颗粒将57例Ⅰ期HCC患者分为联合组(n=29,口服槐耳颗粒)和对照组(n=28,未口服槐耳颗粒)。比较两组患者的无进展生存情况,采用Cox回归模型分析Ⅰ期HCC患者TACE联合槐耳颗粒治疗后疾病进展的影响因素,比较两组患者的不良反应发生情况。结果随访截至TACE治疗后48周,联合组和对照组患者的中位疾病进展时间(TTP)分别为31.2周和24.1周;术后48周,联合组和对照组患者的无进展生存率分别为31.0%和14.3%,联合组患者的无进展生存情况优于对照组(P﹤0.05)。Cox多因素分析结果显示,年龄、Child-Pugh分级、病灶数目以及肿瘤滋养动脉数目均是Ⅰ期HCC患者TACE联合槐耳颗粒治疗后疾病进展的独立影响因素(P﹤0.05)。两组患者消化不良、恶心或呕吐、腹泻、疲劳、血细胞计数异常发生率比较,差异均无统计学意义(P﹥0.05);联合组患者肝功能异常发生率低于对照组,差异有统计学意义(P﹤0.05)。结论TACE联合槐耳颗粒治疗Ⅰ期HCC具有较好的安全性,且可使患者获得更长的TTP以及更好的肝功能状态。Objective To investigate the safety of transcatheter arterial chemoembolization(TACE)combined with huaier granules in the treatment of patients with stage Ⅰ hepatocellular carcinoma(HCC)and its effect on prognosis,and to analyze the influence factors for prognosis.Method A total of 57 patients with stage Ⅰ HCC were divided into combination group(n=29,orally administered of huaier granules)and control group(n=28,without oral administration of huaier granules)according to whether huaier granules were orally administered after TACE treatment.The progression-free survival of the two groups was compared,and the Cox regression model was built to analyze the influence factors for disease progression in patients with stage Ⅰ HCC after TACE combined with huaier granules treatment.The incidence of adverse reactions in the two groups was also compared.Result Follow-up to 48 weeks after TACE treatment,the median time to progression(TTP)of patients in the combination group and control group was 31.2 weeks and 24.1 weeks,respectively.Forty-eight weeks after surgery,the progression-free survival rates of patients in the combination group and control group were 31.0% and 14.3%.The progression-free survival of patients in the combination group was better than that in the control group(P<0.05).Cox multivariate analysis showed that age,Child-Pugh grade,number of lesions,and number of tumor feeding arteries were independent influence factors for disease progression in patients with stage Ⅰ HCC after TACE combined with huaier granules treatment(P<0.05).There were no significant differences in the incidences of dyspepsia,nausea or vomiting,diarrhea,fatigue,and abnormal blood count between the two groups(P>0.05).The incidence of abnormal liver function in the combination group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion TACE combined with huaier granules has reliable safety in the treatment of stage Ⅰ HCC,and can help patients achieve longer TTP and better liver

关 键 词：槐耳颗粒 肝细胞癌 经导管动脉化疗栓塞 疾病进展时间 

分 类 号：R735.7[医药卫生—肿瘤]