机构地区:[1]铜川市人民医院耳鼻喉科,陕西铜川727000 [2]西电集团医院耳鼻喉科,西安710077
出 处:《癌症进展》2022年第13期1385-1388,共4页Oncology Progress
摘 要:目的探讨低温等离子刀治疗早期声门型喉癌的疗效及对患者远期预后的影响。方法依据治疗方法的不同将82例早期声门型喉癌患者分为观察组和对照组,每组41例,对照组患者给予喉部分切开术治疗,观察组患者给予低温等离子刀治疗。比较两组患者的急性时相蛋白[铜蓝蛋白(CER)、C反应蛋白(CRP)、α_(1)-酸性糖蛋白(α_(1)-AG)]、嗓音功能[基频微扰(Jitter)、基频(F0)、声压级(SPL)、最长发声时间(MPT)]、手术相关指标,随访2年,比较两组患者的预后情况。结果治疗后,两组患者CER、CRP、α_(1)-AG水平均高于本组治疗前,但观察组患者CER、CRP、α_(1)-AG水平均低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患者Jitter、F0均高于本组治疗前,SPL均低于本组治疗前,MPT均短于本组治疗前,但观察组患者Jitter、F0均低于对照组,SPL高于对照组,MPT长于对照组,差异均有统计学意义(P﹤0.05)。观察组患者住院时间、手术时间均明显短于对照组,黏膜恢复光滑率明显高于对照组,差异均有统计学意义(P﹤0.01)。随访2年,两组患者局部复发率、淋巴结转移率、远处转移率、病死率比较,差异均无统计学意义(P﹥0.05)。结论低温等离子刀可有效减轻早期声门型喉癌患者喉部应激反应,降低对嗓音功能影响,促进患者恢复,与喉部分切开术的预后无较大差异,临床应用价值较高。Objective To investigate the efficacy of low temperature plasma knife in the treatment of early-stage glottic laryngeal carcinoma and its influence on the long-term prognosis of patients.Method According to different treatment methods,82 patients with early-stage glottic laryngeal carcinoma were divided into observation group(n=41,received low temperature plasma knife)and control group(n=41,received partial laryngectomy).The acute phase protein[ceruloplasmin(CER),C-reactive protein(CRP),α_(1)-acid glycoprotein(α_(1)-AG)],voice function[fundamental frequency perturbation(Jitter),fundamental frequency(F0),sound pressure level(SPL),maximum phonation time(MPT)],and surgical recovery indexes were compared between the two groups,and the patients were followed up for 2 years to compare the prognosis of the two groups of patients.Result After treatment,the levels of CER,CRP andα_(1)-AG in the two groups were higher than those before treatment,but the levels of CER,CRP andα_(1)-AG in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,Jitter and F0 in the two groups were higher than those before treatment,SPL were lower than those before treatment,and MPT were shorter than those before treatment,However,Jitter and F0 in the observation group were lower than those in the control group,SPL was higher than that in the control group,and MPT was longer than that in the control group,the differences were statistically significant(P<0.05).The hospitalization time and operation time of the observation group were significantly shorter than those of the control group,and the mucosal recovery rate was significantly higher than that of the control group,the differences were statistically significant(P<0.01).During the 2-year follow-up,there were no significant differences in the local recurrence rate,lymph node metastasis rate,distant metastasis rate and mortality rate between the two groups(P>0.05).Conclusion Low-temperature plasma knife can effe
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