免疫检查点在皮肤肿瘤中的研究进展  

Immune checkpoints in skin tumors

作　　者：刘亭亭 刘红[1] 张福仁[1] LIU Tingting;LIU Hong;ZHANG Furen(Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250022,China)

机构地区：[1]山东第一医科大学附属皮肤病医院(山东省皮肤病医院),山东省皮肤病性病防治研究所,济南250022

出　　处：《中国麻风皮肤病杂志》2022年第10期752-758,共7页China Journal of Leprosy and Skin Diseases

基　　金：山东省重点研发计划(重大科技创新工程)项目(编号:2021LCZX07);山东省自然科学基金项目(编号:ZR2018BC020)。

摘　　要：近年来研究发现,免疫检查点(CTLA-4、PD-1、TIM-3、TIGIT和LAG-3等)表达于免疫细胞表面,与肿瘤的增殖、侵袭和转移紧密相关。免疫检查点抑制剂,已广泛地应用于皮肤肿瘤的临床治疗,并取得了显著的疗效。本文将从免疫检查点的类型、作用机制、其在皮肤肿瘤中的研究及临床应用等方面进行系统综述。Recent studies show that immune checkpoints(CTLA-4,PD-1,TIM-3,TIGIT and LAG-3)are expressed on the surface of immune cells,and are associated with the proliferation,invasion,metastasis of tumor cells.Immune checkpoint inhibitors have been widely used in the clinical treatment of skin tumors and have achieved remarkable efficacy.In this review,we discuss the mechanisms and clinical applications of different kinds of immune checkpoints in skin tumors.

关 键 词：免疫检查点 免疫检查点抑制剂 皮肤肿瘤 

分 类 号：R739.5[医药卫生—肿瘤]