青少年抑郁患者在言语流畅性任务下脑氧合血红蛋白水平的变化  

Changes of brain oxygenated hemoglobin concentration in adolescent patients with depression under speech fluency task

作　　者：程奥博 樊家琦 刘力慧 刘晋宁 张丽丽[5] 王红英[5] 张云淑[5] 杨建利[2] 栗克清[5] Cheng Aobo;Fan Jiaqi;Liu Lihui;Liu Jinning;Zhang Lili;Wang Hongying;Zhang Yunshu;Yang Jianli;Li Keqing(Chinese and Western Medicine Unit,Kailuan Mental Health Centre,Tangshan 063000,China;College of Electronic and Information Engineering,Hebei University,Baoding 071000,China;Graduate School of North China University of Science and Technology,Tangshan 063210,China;School of Public Health,Hebei University,Baoding 071000,China;Hebei Sixth People's Hospital,Baoding 071000,China)

机构地区：[1]开滦精神卫生中心中西医病区,唐山063000 [2]河北大学电子信息工程学院,保定071000 [3]华北理工大学研究生院,唐山063210 [4]河北大学公共卫生学院,保定071000 [5]河北省第六人民医院,保定071000

出　　处：《中华行为医学与脑科学杂志》2022年第7期629-633,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：河北省医学适用技术跟踪项目(G2021091)。

摘　　要：目的基于功能性近红外光谱成像技术探索青少年抑郁障碍患者与健康青少年在言语流畅性任务中各个脑区氧合血红蛋白反应特征及差异。方法本研究于2021年3月至2021年6月纳入29例青少年抑郁症患者(抑郁组)和26名健康青少年(健康组)。采用汉密尔顿抑郁量表评分评估患者抑郁严重程度;并应用近红外脑功能成像仪进行言语流畅性任务,测量前额叶及两侧颞叶氧合血红蛋白相对浓度变化。使用SPSS 26.0统计软件进行数据统计,性别计数资料采用卡方检验,两组间比较采用t检验,不符合正态分布的计量资料两组间比较采用Mann-WhitneyU检验。结果在言语流畅性任务中,青少年抑郁组前额叶氧合血红蛋白浓度及左侧颞叶的氧合血红蛋白浓度与健康组比较均差异无统计学意义(均P>0.05),右侧颞叶氧合血红蛋白浓度[-9.179(-22.231,4.789)]明显低于健康组[12.754(-9.438,35.008)],差异有统计学意义(U=538.00,P<0.05)。青少年抑郁组右侧颞叶氧合血红蛋白浓度与汉密尔顿抑郁量表评分无相关性(r=0.092,P>0.05)。结论青少年抑郁患者在进行言语流畅性任务时右侧颞叶区功能低于健康青少年,为进一步研究抑郁情绪及部分认知灵敏性损害与右侧颞叶功能的关系提供依据。Objective To explore the characteristics and differences of oxygenated hemoglobin responses in different brain regions in adolescent depressive disorder patients and healthy adolescents during speech fluency task based on functional near-infrared spectroscopy imaging.Methods From March 2021 to June 2021,twenty-nine adolescents with depression(depressed group)and 26 healthy adolescents(normal group)were enrolled.The severity of depression was assessed by Hamilton depression scale,and the speech fluency task was performed by functional near-infrared spectroscopy brain imaging,and the relative concentrations of oxyhemoglobin in the prefrontal and bilateral temporal lobes were measured.SPSS 26.0 statistical software was used for data analysis,chi-square test was used for gender count data.The t-test was used for comparison of two groups.The measurement data that did not conform to normal distribution were compared between the two groups by Mann-Whitney U test.Results In the speech fluency task,there was no significant difference in the concentration of oxygenated hemoglobin in prefrontal and left temporal between the depressed group and the normal group(both P>0.05);the oxygenated hemoglobin concentration in the right temporal lobe(-9.179(-22.231,4.789))of depressed group was significantly lower than that of the normal group(12.754(-9.438,35.008)),and the difference was statistically significant(U=538.00,P<0.05).The oxygenated hemoglobin concentration in right temporal lobe of depressed group had no correlation with the score of Hamilton depression rating scale(r=0.092,P>0.05).Conclusion The right temporal lobe function of adolescent depression patients is lower than that of healthy controls during speech fluency tasks,which provides a basis for study of the relationship between depression and some cognitive sensitivity impairment and the function of right temporal lobe.

关 键 词：功能性近红外光谱成像 言语流畅性任务 青少年抑郁 认知功能 氧合血红蛋白 

分 类 号：R749.4[医药卫生—神经病学与精神病学]