Dlx基因调控颌面部发育的研究进展  

Research progress on Dlx homeobox gene regulating maxillofacial development

作　　者：张艺馨(综述) 温秀杰(审校) ZHANG Yixin;WEN Xiujie(Department of Orthodontics,the Affiliated Stomatology Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China;Department of Orthodontics,Chongqing Ruitai Stomatological Hospital,Chongqing 401121,China)

机构地区：[1]西南医科大学附属口腔医院正畸科,四川泸州646000 [2]重庆瑞泰口腔医院正畸科,401121

出　　处：《重庆医学》2022年第15期2678-2681,共4页Chongqing medicine

基　　金：国家自然科学基金项目(81970906);四川省科技计划项目(2019YJ0689)。

摘　　要：远端较小同源盒(Dlx)基因属于同源盒基因家族的一员,在脊椎动物生物学的各个方面发挥着重要的调节作用,包括控制肢体的形成、神经元亚群的分化及与神经嵴相关的各种功能。大量研究表明,Dlx基因可以通过调控成牙、成骨过程,影响上下颌骨、腭和牙等的发育,在颌面部发育中发挥至关重要的作用。本文就Dlx基因家族对颌面部发育的调控作用与机制的最新研究进展进行综述,以期为口腔医学领域组织工程再生的研究提供新思路。The distal-homeobox(Dlx)gene belongs to a member of the homogenous box gene family and plays an important regulatory roles in various aspects of vertebrate biology,including the control of limb formation,differentiation of neuronal subgroups and various functions associated with the neural crest.Numerous studies have shown that the Dlx genes can play a crucial role in the development of the mandible and maxilla,palate and teeth by regulating the processes of odontogenesis and osteogenesis.This paper reviews the latest research progress on the regulatory role and mechanism of Dlx gene family on maxillofacial development in order to provide the new ideas for the research on tissue engineering regeneration in stomatological medicine domain.

关 键 词：远端较小同源盒基因 同源盒基因 颌面部发育 成骨发育 成牙发育 

分 类 号：R394[医药卫生—医学遗传学]