噬菌体展示技术及其在抗病毒药物发现中的应用  

Phage display technology and its application in antivirals discovery

作　　者：许世琦 贺子涵 陶炳灼 秦鑫[1] XU Shi-qi;HE Zi-han;TAO Bing-zhuo;QIN Xin(Department of Basic Medicine,Hubei University of Arts and Sciences,Xiangyang 441053,China)

机构地区：[1]湖北文理学院基础医学院,湖北襄阳441053

出　　处：《药学学报》2022年第7期1937-1945,共9页Acta Pharmaceutica Sinica

基　　金：湖北省高等学校优秀中青年科技创新团队项目(T2020016);襄阳市科技局科技计划项目重点项目(2021YL49);湖北文理学院校级科技创新团队项目(2020kypytd004)。

摘　　要：新冠肺炎的大暴发再次引起了人们对于病毒感染性疾病的关注,研发抗病毒药物对于已知的和可能新出现的病毒都具有重要意义。近年来,多肽和蛋白质类药物正成为抗病毒药物研发领域的热点,噬菌体展示技术作为筛选发现多肽和蛋白类药物的有力工具也日益被学术界和工业界所关注。本文介绍了噬菌体展示技术的基本原理,对常用于抗病毒药物发现的噬菌体展示文库进行了总结,对目前噬菌体文库来源的抗病毒药物的不足及其相关改进策略进行了讨论,并对噬菌体展示技术在抗病毒药物开发中的应用前景进行了展望。The COVID-19 outbreak has drawn attention to viral infectious diseases once again, and the development of antiviral drugs for both known and potentially emerging viruses is of great significance. In recent years, peptides and protein drugs are becoming a hot spot in the field of antiviral drug research and development.Phage display technology, as a powerful tool for screening peptides and protein drugs, has been increasingly concerned in the academic and industrial fields. The present review introduced the basic principle of phage display technology, summarized phage display libraries often used in antiviral drug discovery and their applications,discussed the challenges and future direction of antiviral drug research and development based on phage display technology.

关 键 词：噬菌体展示技术 抗病毒药物 病毒感染性疾病 多肽 蛋白 

分 类 号：R966[医药卫生—药理学]