血清Toll样受体、白介素1- β水平与急性脑梗死患者梗 死面积和预后的相关性探讨  

Serum toll like receptor,interleukin-1-13 Study on the correlation between serum levels and infarct size and prognosis in patients with acute cerebral infarction

作　　者：张英 郑慧娟 刘慧琴 ZHANG Ying;ZHENG Hui-juan;LIU Hui-qin(Henan Provincial People's Hospital/Department of laboratory,people's Hospital of Zhengzhou University,Henan Zhengzhou 450000)

机构地区：[1]河南省人民医院/郑州大学人民医院检验科,河南郑州450000

出　　处：《医学检验与临床》2022年第6期17-20,共4页Medical Laboratory Science and Clinics

摘　　要：目的:探讨血清Toll样受体(TLR)、白介素1-β(IL-1β)水平与急性脑梗死患者梗死面积和预后的相关性。方法:选取医院收治的80例急性脑梗死患者作为研究对象(选取时间:2019年3月-2021年5月),作研究组,另纳入30例同期入院体检的健康者作对照组,对比两组TLR指标(TLR2、TLR4)水平和IL-1β水平。治疗后,研究组恋者根据美国国立卫生研究院卒中量表(NIHSS)评分,分为预后不良组和预后良好组,并采用单因素、多因素logistic回归分析及Pearson相关性分析,确定血清TLR2、TLR4和IL-1β水平变化与急性脑梗死患者的梗死面积和预后的相关性。结果:相较对照组,研究组患者血清TLR2、TLR4、IL-1β水平显著偏高(P<0.05);80例患者中预后良好组51例,预后不良组29例,其中预后良好组患者血压水平、NIHSS评分、TLR2水平、TLR4水平、IL-1β水平、高血压史占比、冠心病史占比低于预后不良组,梗死面积小于预后不良组(P<0.05);经Logistic回归分析结果显示,NIHSS评分TLR2水平、TLR4水平、IL-1β水平、梗死面积为评估急性脑梗死患者预后的独立影响因素(P<0.05);经Pearson相关性分析,血清TLR2、TLR4、IL-1β水平与急性脑梗死患者的梗死面积、NIHSS评分均呈正相关(P<0.05)。结论:急性脑梗死患者血清中TLR2、TLR4、IL-1β水平均表达异常,与梗死面积和患者预后呈明显相关性,在临床动态监测,可为早期对患者梗死情况及预后评估提供数据支持,有较高应用价值。Objective:To investigate the levels of Toll like receptor(TLR) and interleukin-1 in serum-β(IL-1β)The correlation between serum glucose level and infarct size and prognosis in patients with acute cerebral inferction Methods:80 patients with acute cerebral infarction treated in the hospital were selected as the study group(selected from March 2019 to may 2021),and 30 healthy subjects admitted for physical examination at the same time were included as the control group.The levels of TLR indicators(TLR2,TLR4)and IL-1 were compared between the two groups β Level.After treatment,the patients in the study group were divided into poor prognosis group and good prognosis group according to the National Institutes of Health Stroke Scale(NIHSS)score,and the serum TLR2,TLR4 and IL-1 were determined by univariate and multivariate logistic regression analysis and Pearson correlation analysis β The correlation between the level change and the inferct size and prognosis of patients with acute cerebral infarction Results:Compared with the control group,the serum TLR2,TLR4 and IL-1 in the study group β The level was significandy higher(P<0.05);Among the 80 patients,51 were in the good prognosis group and 29 were in the poor prognosis group,including blood pressure level,NIHSS score,TLR2 level,TLR.4 level and IL-1 in the good prognosis group β The level,the proportion of hypertension history and coronary heart disease history were lower than those in poor prognosis group,and the infarct area was smaller than those in poor prognosis group(P<0.05);Logistic regression analysis showed that NIHSS score TLR2 level,TLR.4 level and IL-1β Level and infarct size were the independent influeiicing factors to evaluate the prognosis of patients with acute cerebral inferction(P<0.05);By Pearson correlation analysis,serum TLR2,TLR4,IL-1β There was a positive correlation between the level and the infarct size and NIHSS score in patients with acute cerebral infarction(P<0.05).Conclusion:The expression of TLR2,TLR4 and IL-1β in serum of pati

关 键 词：急性脑梗死 梗死面积 预后 相关性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]