抑郁障碍与精神分裂症患者认知功能损害分析  

Analysis of cognitive impairment in patients with major depressive disorder and schizophrenia

作　　者：姜文慧 李烨[1] 贾敏[1] 董莹莹[1] 王崴[1] 高成阁[1] 陈策[1] JIANG Wen-hui;LI Ye;JIA Min;DONG Ying-ying;WANG Wei;GAO Cheng-ge;CHEN Ce(Department of Psychiatry,the First Affiliated Hospital of Medical College of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院精神心理卫生科,710061

出　　处：《临床精神医学杂志》2022年第4期301-303,共3页Journal of Clinical Psychiatry

基　　金：陕西省重点研发计划一般项目社会发展领域(2021SF-090)。

摘　　要：目的:探讨抑郁障碍和精神分裂症患者认知功能损害特点及与临床症状的关系。方法:采用CogState量表(CSB)对107例抑郁障碍患者(抑郁障碍组)、129例精神分裂症患者(精神分裂症组)及73名年龄、文化程度等与患者相匹配的健康对照者(健康对照组)行认知功能评估;采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、蒙哥马利-斯伯格抑郁评定量表(MADRS)及阳性与阴性症状量表(PANSS)进行临床症状评估。结果:CSB评分显示,抑郁障碍组和精神分裂症组视觉记忆、工作记忆及听觉性语言记忆得分明显低于健康对照组;精神分裂症组视觉记忆及工作记忆得分明显低于抑郁障碍组(P<0.05或P<0.01)。抑郁障碍组CSB视觉记忆及工作记忆得分与HAMD、HAMA、MADRS评分呈负相关;精神分裂症组CSB工作记忆与PANSS总分、阴性症状及一般病理症状评分呈负相关(P<0.05或P<0.01)。结论:抑郁障碍和精神分裂症患者均存在认知功能损害,且损害程度与临床症状严重程度相关;其中精神分裂症患者的视觉记忆、工作记忆损害较抑郁障碍患者更明显。Objective:To explore the characteristics of cognitive impairment in patients with depression and schizophrenia and its relationship with clinical symptoms.Method:Depression patients(n=107)and schizophrenia patients(n=129)were selected according to the strict screening and exclusion criteria.Control group(n=73),who matched at age,gender and education,were also selected according to the corresponding enrollment criteria.CogState Battery(CSB)was used to evaluate all subjects.Hamilton Depression Rating Scale(HAMD),Hamilton Anxiety Scale(HAMA),Montgomery-Asberg Depression Rating Scale(MADRS)and Positive and Negative Symptom Scale(PANSS)were used to evaluate clinical symptoms.Results:According to the CSB results,the scores of visual memory,working memory and auditory language memory in the depression group and schizophrenia group were significantly lower than those in the healthy control group;the scores of visual memory and working memory in schizophrenia group were significantly lower than those in the depression group(P<0.05 or P<0.01).The scores of visual memory and working memory of the depression group were negatively correlated with the scores of HAMD,HAMA and MADRS;the working memory of the schizophrenia group was negatively correlated with the total score of PANSS,negative symptoms and general pathological symptoms(P<0.05 or P<0.01).Conclusion:Both patients with depression and schizophrenia have cognitive impairment,and the degree of impairment is related to the severity of clinical symptoms.The impairment of visual memory and working memory in schizophrenia patients are more obvious than those in depression patients.

关 键 词：抑郁障碍 精神分裂症 认知功能 

分 类 号：R749[医药卫生—神经病学与精神病学]