急性进展性脑梗死患者血清炎症因子水平和凝血功能变化及其临床意义  

Changes of serum inflammatory factor levels and coagulation function in patients with acute progressive cerebral infarction and their clinical significance

作　　者：程相杰[1] 宋彦[1] 赵晓玲[1] 徐连营[1] 张誓伟[1] 高方 杨牧[1] 郑珂珂 CHENG Xiangjie;SONG Yan;ZHAO Xiaoling;XU Lianying;ZHANG Shiwei;GAO Fang;YANG Mu;ZHENG Keke(Department of Neurology,Nanyang Second General Hospital,Nanyang 473400,Henan Province,China)

机构地区：[1]南阳市第二人民医院神经内科,河南南阳473400

出　　处：《新乡医学院学报》2022年第8期752-755,共4页Journal of Xinxiang Medical University

基　　金：河南省医学科技攻关计划(联合共建)项目(编号:LHGJ20191467)。

摘　　要：目的探讨急性进展性脑梗死(APCI)患者血清炎症因子水平及凝血功能的变化及临床意义。方法选择2019年6月至2020年12月南阳市第二人民医院收治的72例APCI患者为APCI组,另选择72例非急性进展性脑梗死(NPCI)患者为NPCI组,同时选择72例体检健康者为健康对照组。健康对照组受试者于体检当日、APCI组和NPCI组患者于入院第1、3、7、14天采用双抗体夹心法检测血清白细胞介素-18(IL-18)、肿瘤坏死因子-α(TNF-α)水平,采用免疫比浊法检测血清白细胞介素-6(IL-6)、前白蛋白(PA)水平;健康对照组受试者于体检当日、APCI组和NPCI组患者于入院次日使用全自动血凝分析仪检测血浆纤维蛋白原(FIB)水平、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)和凝血酶原时间(PT)。结果入院第1、3、7、14天,APCI组和NPCI组患者血清IL-6、IL-18、TNF-α水平显著高于健康对照组,血清PA水平显著低于健康对照组(P<0.05);入院第1、3、7、14天,APCI组患者血清IL-6、IL-18、TNF-α水平显著高于NPCI组,血清PA水平显著低于NPCI组(P<0.05)。3组受试者血浆FIB水平及TT、APTT、PT比较差异均有统计学意义(P<0.05)。APCI组和NPCI组患者血浆FIB水平显著高于健康对照组,TT、APTT、PT显著短于健康对照组(P<0.05);APCI组患者血浆FIB水平显著高于NPCI组,TT、APTT、PT显著短于NPCI组(P<0.05)。结论APCI患者血清炎症因子表达及凝血功能异常,血清炎症因子水平及血液凝血功能检查有助于对APCI的诊断及患者病情评估。Objective To investigate the changes and clinical significance of serum inflammatory factor levels and coagulation function in patients with acute progressive cerebral infarction(APCI).Methods Seventy-two APCI patients admitted to Nanyang Second General Hospital from June 2019 to December 2020 were selected as the APCI group,and another 72 patients with non-acute progressive cerebral infarction(NPCI)were selected as the NPCI group,and 72 healthy individuals were selected as the healthy control group.On the day of physical examination and the 1^(st),3^(rd),7^(th) and 14^(th) day after admission,the levels of serum interleukin-18(IL-18)and tumor necrosis factor-α(TNF-α)were detected by double-antibody sandwich method,and the levels of serum interleukin-6(IL-6)and prealbumin(PA)were detected by immunoturbidimetry.On the day of physical examination and the next day after admission,the plasma fibrinogen(FIB)level,thrombin time(TT),activated partial thromboplastin time(APTT)and prothrombin time(PT)were measured by automatic hemagglutination analyzer.Results On the 1^(st),3^(rd),7^(th) and 14^(th) day after admission,the levels of serum IL-6,IL-18 and TNF-αof patients in the APCI group and NPCI group were significantly higher than those in the healthy control group,and the serum PA level of patients in the APCI group and NPCI group was significantly lower than that in the healthy control group(P<0.05);the levels of serum IL-6,IL-18 and TNF-αof patients in the APCI group were significantly higher than those in the NPCI group,and the serum PA level of patients in the APCI group was significantly lower than that in the NPCI group(P<0.05).There were significant differences in plasma FIB level,TT,APTT and PT among the three groups(P<0.05).The level of plasma FIB of patients in the APCI group and NPCI group was significantly higher than that in the healthy control group,and the TT,APTT and PT of patients in the APCI group and NPCI group were significantly shorter than those in the healthy control group(P<0.05).The plasma

关 键 词：急性进展性脑梗死 炎症因子 凝血功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]