盐酸小檗碱联合二甲双胍治疗非酒精性脂肪肝患者的效果  

Effects of Berberine hydrochloride combined with Metformin in treatment of patients with non-alcoholic fatty liver

作　　者：赵亚楠 李彩 刘龙 陈静[1] 吴凤娟 刘娜[1] ZHAO Ya'nan;LI Cai;LIU Long;CHEN Jing;WU Fengjuan;LIU Na(Department of Gastroenterology of Zhengzhou No.1 People’s Hospital,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州市第一人民医院消化内科,河南郑州450000

出　　处：《中国民康医学》2022年第14期51-53,57,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察盐酸小檗碱联合二甲双胍治疗非酒精性脂肪肝(NAFLD)患者的效果。方法:选取2018年2月至2020年2月该院收治的80例NAFLD患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各40例。对照组采用二甲双胍治疗,观察组在对照组基础上联合盐酸小檗碱治疗,比较两组临床疗效,治疗前后血清指标[白细胞介素-17(IL-17)、转化生长因子-β(TGF-β)]水平,血脂指标[总胆固醇(TC)、三酰甘油(TG)]水平,肝功能指标[γ-谷氨酰转肽酶(GGT)、谷氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)]水平及不良反应发生率。结果:观察组治疗总有效率为95.00%,高于对照组的77.50%,差异有统计学意义(P<0.05);治疗后,观察组IL-17、TGF-β水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组TC、TG水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组GGT、AST及ALT水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸小檗碱联合二甲双胍治疗NAFLD患者,可提高临床疗效,降低IL-17和TGF-β水平,改善血脂指标和肝功能指标水平,其效果优于单纯二甲双胍治疗。Objective:To observe effects of Berberine hydrochloride combined with Metformin in treatment of patients with non-alcoholic fatty liver(NAFLD).Methods:80 NAFLD patients admitted to our hospital from February 2018 to February 2020 were selected for the prospective study,and were divided into control group and observation group according to the random number table method,40 cases in each group.The control group was treated with Metformin,while the observation group was treated with Berberine hydrochloride on the basis of that of the control group.The clinical efficacy,the serum index levels[interleukin-17(IL-17),transforming growth factor-beta(TGF-β)],the blood lipid index levels[total cholesterol(TC),triacylglycerol(TG)],the liver function index levels[γ-glutamyl transpeptidase(GGT),glutamate aminotransferase(AST),alanine aminotransferase(ALT)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 95.00%,which was higher than 77.50%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IL-17 and TGF-βin the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the TC and TG of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of GGT,AST and ALT in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Berberine hydrochloride combined with Metformin in the treatment of the NAFLD patients can improve the clinical efficacy,reduce the levels of IL-17 and TGF-β,and improve the levels of blood lipids indexes and liver function indexes.Moreover,it is superio

关 键 词：非酒精性脂肪肝 二甲双胍 盐酸小檗碱 血脂 肝功能 不良反应 

分 类 号：R575.5[医药卫生—消化系统]