睡眠障碍与阿尔茨海默病相关性的研究进展  

Research progress on the relationship between sleep disorders and Alzheimer’s disease

作　　者：王修 唐伟[1] 谭丽阳[1] 王威[2] WANG Xiu;TANG Wei;TAN Liyang;WANG Wei(Xinhua Hospital,Dalian University,Dalian 116621,China;Zhongshan Hospital,Dalian University,Dalian 116001,China)

机构地区：[1]大连大学附属新华医院,辽宁大连116021 [2]大连大学附属中山医院,辽宁大连116001

出　　处：《中国实用神经疾病杂志》2022年第6期781-784,共4页Chinese Journal of Practical Nervous Diseases

基　　金：大连市卫计委科研课题项目(编号:2011049)。

摘　　要：睡眠障碍是阿尔茨海默病(AD)的常见症状,通常被认为是神经退行性过程的晚期后果。最近研究表明,睡眠障碍通常发生在疾病的早期,甚至可能先于认知症状出现。此外,睡眠-觉醒周期似乎可以调节大脑中致病的β淀粉样蛋白(Aβ)水平,并通过多种机制影响小鼠模型中与AD相关的病理。最后,睡眠剥夺似乎加剧了小鼠的Aβ病理,并且除了Aβ的改变外,睡眠剥夺可通过多种机制介导Aβ非依赖性神经元损伤。本综述研究了睡眠障碍可能影响AD发病机制的有关文献,并深入探讨其可能的机制。Sleep disturbances are a common symptom of Alzheimer’s disease(AD)and are often consid⁃ered a late consequence of neurodegenerative processes.Recent studies have shown that sleep disturbances usually occur early in the course of the disease and may even precede the appearance of cognitive symptoms.In addition,sleep-wake cycles appear to regulate levels of pathogenicβamyloid(Aβ)in the brain and influence AD-as⁃sociated pathologies in mouse models through multiple mechanisms.Finally,sleep deprivation appears to exacer⁃bate Aβpathology in mice,and in addition to alterations in Aβ,sleep deprivation can mediate Aβnon-dependent neuronal damage through a variety of mechanisms.This review examines the literature that sleep disorders may af⁃fect the pathogenesis of AD and explores its possible mechanisms in depth.

关 键 词：阿尔茨海默病 睡眠障碍 睡眠-觉醒周期 睡眠剥夺 Β淀粉样蛋白 

分 类 号：R749.16[医药卫生—神经病学与精神病学]