IL-4调控小胶质细胞极化在血管性认知障碍中的作用机制研究进展  

Research progress on the mechanism of IL-4 regulating microglia polarization in vascular cognitive impairment

作　　者：李倩倩[1,2] 李小黎[3] 陈雨菲 崔莹雪 王少松[1] 王曦[2] 田伟[1] LI Qianqian;LI Xiaoli;CHEN Yufei;CUI Yingxue;WANG Shaosong;WANG Xi;TIAN Wei(Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University,Beijing 100010,China;Beijing University of traditional Chinese medicine,Beijing 100105,China;The Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010 [2]北京中医药大学,北京100105 [3]北京中医药大学第三附属医院,北京100029

出　　处：《中国实用神经疾病杂志》2022年第6期785-788,共4页Chinese Journal of Practical Nervous Diseases

基　　金：国家自然科学基金项目(编号:82104997)。

摘　　要：血管性痴呆(vascular dementia,VD)的核心症状是认知功能障碍。大脑缺血后小胶质细胞被激活,进而诱导神经炎症反应是血管性认知功能障碍发生的关键。既往部分研究认为,小胶质细胞在病理状态下主要发挥促炎作用,但近年来越来越多的研究发现,小胶质细胞极化后的不同表型可发挥不同的作用,提示小胶质细胞极化在VD机制研究中的重要地位。白细胞介素-4(interleukin-4,IL-4)作为诱导小胶质细胞从促炎的M1表型极化到抗炎的M2表型的重要调节因子,已被证明与学习认知的病理过程密切相关。本文着重对小胶质细胞极化在血管性认知障碍中的研究进展及IL-4在小胶质细胞极化转化过程中的作用机制进行综述,以期为血管性痴呆的治疗提供新的思路。The core symptom of vascular dementia(VD)is cognitive dysfunction.After cerebral ischemia,microglia are activated to induce neuroinflammatory response,which is the key to vascular cognitive impairment.Some previous studies believe that microglia mainly play a pro-inflammatory role in pathological state.But in recent years,more and more studies have found that different phenotypes of microglia after polarization can play different roles,suggesting that microglia polarization plays an important role in the mechanism of VD.As an important regulator of microglia polarization from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype,interleukin-4(IL-4)has been proved to be closely related to the pathological process of learning and cognition.Therefore,this paper focuses on the research progress of microglia polarization in vascular cognitive impairment and the mechanism of IL-4 in the process of microglia polarization transformation,in order to find a new treatment strategy for VD.

关 键 词：血管性痴呆 认知功能障碍 小胶质细胞极化 白细胞介素-4 炎症机制 

分 类 号：R749.16[医药卫生—神经病学与精神病学]