《药物合成新技术》课程“三位一体”人才培养模式教学改革与实践  

Teaching Reform and Practice of"Trinity"Talent Training Mode in the Course of New Technology of Drug Synthesis

作　　者：叶向阳 惠子 何兴瑞 王丽薇[1] 谢恬[1] YE Xiangyang;HUI Zi;HE Xingrui;WANG Liwei;XIE Tian(School of Pharmacy,Hangzhou Normal University,Zhejiang Hangzhou 311121,China)

机构地区：[1]杭州师范大学药学院,浙江杭州311121

出　　处：《中国医药导刊》2022年第6期577-580,共4页Chinese Journal of Medicinal Guide

基　　金：国家自然科学基金资助项目(项目编号:82073686,项目名称:靶向AAK1的抗冠状病毒候选药物研究:设计合成、构效关系研究及作用机制探索);杭州市“115”引进国(境)外智力项目计划(项目编号:20200215,项目名称:新型AAK1抑制剂的合成和在抗冠状病毒感染上的应用,项目编号:20210120,项目名称:新型AAK1抑制剂的合成和在抗冠状病毒感染上的应用(二));杭州师范大学卓越人才计划科研启动基金(项目编号:2019QDL003,项目名称:基于榄香烯的多靶点、多通路的新药研发);国家科技部外国专家项目(项目编号:G20200217005,项目名称:基于组蛋白去乙酰化酶和热休克蛋白的双通路抑制剂的研究、开发和在治疗上的应用,项目编号:G2021017004,项目名称:AAK1-HDACs双通路抑制剂的设计、合成及在抗病毒的药效机制研究)。

摘　　要：目的:我院在《药物合成新技术》课程教学中,通过开展教学-科研实践-科技竞赛“三位一体”人才培养模式教学改革与实践,提升学生的科技创新能力,为培养优秀的药物合成、药物开发与药物生产研究科研人员、工程技术人员奠定基础。方法:组建师生合作型教师队伍,构建用于教学的药物合成科研平台,改革教学内容,强化研究型教学内容,注重科研思维培养,为药学专业学生提供科研训练、科技创新竞赛指导与技术支持。结果与结论:通过两个教学周期的改革与实践,我院学生在药物合成基础知识掌握、科研实验设计与实践操作能力方面都得到了明显提升;同时在课程组教师的指导下,学生获得省级、市级和校级多个科技创新项目立项,以第一作者发表SCI论文2篇,参与申请发明专利3项,课程建设获得2项教学改革项目立项。本课程的教学改革与实践为其他医药类课程开展“三位一体”的人才培养模式教学改革提供借鉴。Objective:To implement the teaching reform and practice of the"Trinity"talent training mode of teaching,research practice,and science&technology contest in the course of New Technology of Drug Synthesis,so as to improve the scientific and technological innovation ability of students,and lay a foundation for training excellent scientific researchers,engineers and technicians in drug synthesis,drug development and drug production research.Methods:The course team established a teacher-student cooperative team expertizing in both teaching and scientific research,constructed a drug synthesis scientific research platform for teaching purpose,reformed the teaching content for the course,focused on the cultivation of scientific research thinking,strengthened research-based teaching content,and provided scientific research training,innovation contest guidance and technical support for the students.Results and Conclusion:Through the reform and practice of two teaching cycles,students′basic knowledge of drug synthesis,scientific research and experimental design ability as well as practical operation ability have been effectively improved.At the same time,under the guidance of the course team,some students obtained science and technology innovation project approval at provincial,municipal and school levels,and published two SCI papers as the first author,participated in three invention patent applications.The teachers also obtained two teaching reform projects.The teaching reform and practice of New Technology of Drug Synthesis course provide a reference for other medical courses to carry out the"Trinity"talent training mode teaching reform.

关 键 词：《药物合成新技术》 三位一体 科技创新 人才培养模式 

分 类 号：G42[文化科学—课程与教学论]