麦角硫因的生物合成及提取检测  

The biosynthesis, extraction and detection of ergothioneine

作　　者：田缘 闫更轩 于冲[1] 胡基华[1] 陈盛宇 叶阳[1] 田洁萍[1] 潘钰[1] TIAN Yuan;YAN Gengxuan;YU Chong;HU Jihua;CHEN Shengyu;YE Yang;TIAN Jieping;PAN Yu(Institute of Microbiology,Heilongjiang Academy of Sciences,Harbin 150010,China)

机构地区：[1]黑龙江省科学院微生物研究所,哈尔滨150010

出　　处：《生命的化学》2022年第6期1076-1082,共7页Chemistry of Life

基　　金：黑龙江省自然科学基金重点项目(ZD2020C010);黑龙江省科学院青年创新基金项目(CXMS2022SW01)。

摘　　要：麦角硫因是一种独特的天然手性氨基酸,通常由细菌和真菌生物合成。作为一种食品来源的抗氧化剂和细胞保护剂,它在食品、保健品、化妆品、生物医学等领域展现出广阔的应用前景。本文总结了麦角硫因生物合成途径及几种高效提取、检测麦角硫因的方法,旨在由分子层面深入了解麦角硫因生物合成的调控机理,进而结合代谢调控提高麦角硫因的生物合成水平,为生物活性物质的合理开发和利用奠定基础。Ergothioneine is a unique natural chiral amino acid that is normally biosynthesized by bacteria and fungi. As a food-derived antioxidant and cell protectant, it shows broad application prospects in the fields of food, health products, cosmetics and biomedicine. This paper summarizes the biosynthetic pathway of ergothioneine and its extraction and detection methods, aiming to deeply understand the regulatory mechanism of ergothioneine biosynthesis at the molecular level, and then combine metabolic regulation to improve the level of ergothioneine biosynthesis, which lays the foundation for the rational development and utilization of biologically active substances.

关 键 词：麦角硫因 生物合成 提取 检测 

分 类 号：TQ28[化学工程—有机化工]