血清sTREM-1、sCD14和PCT水平对白内障术后患者眼内炎及前房积脓的诊断价值  

The diagnostic value of serum sTREM-1,sCD14 and PCT levels in endophthalmitis and hypopyon in patients after cataract surgery

作　　者：江立 JIANG Li(Department of Ophthalmology,Jiangwan Hospital of Hongkou District,Shanghai 200434,China)

机构地区：[1]上海市虹口区江湾医院眼科,上海200434

出　　处：《检验医学与临床》2022年第16期2215-2219,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨血清可溶性髓系细胞触发受体-1(sTREM-1)、可溶性白细胞分化抗原14(sCD14)和降钙素原(PCT)水平对白内障术后患者眼内炎和前房积脓的诊断价值。方法选择2015年1月至2020年12月在该院行白内障术后发生眼内炎的患者98例(98眼)为眼内炎组,其中前房积脓44例为前房积脓组,非前房积脓54例为非前房积脓组。选择同期在该院行白内障术后无感染者65例(65眼)为对照组。采用酶联免疫吸附试验检测各组术后1、3 d血清sTREM-1、sCD14和PCT水平。比较眼内炎组和对照组术后1、3 d血清sTREM-1、sCD14和PCT水平;比较术后3 d前房积脓组与非前房积脓组患者血清sTREM-1、sCD14和PCT水平;分析术后3 d血清sTREM-1、sCD14和PCT单独及联合检测对眼内炎及前房积脓的诊断效能。结果术后3 d眼内炎组血清sTREM-1、sCD14和PCT水平明显高于术后1 d和对照组,差异有统计学意义(P<0.05)。术后3 d血清sTREM-1、sCD14和PCT联合检测诊断白内障术后眼内炎的灵敏度为87.8%,特异度为90.8%,曲线下面积(AUC)为0.952,明显高于各指标单独检测(P<0.05)。术后3 d前房积脓组血清sTREM-1、sCD14和PCT水平明显高于非前房积脓组,差异有统计学意义(P<0.05)。术后3 d血清sTREM-1、sCD14和PCT联合检测诊断白内障术后前房积脓的灵敏度为84.1%,特异度为98.1%,AUC为0.970,明显高于各指标单独检测(P<0.05)。术后3 d眼内炎患者血清sTREM-1水平与sCD14和PCT水平呈正相关(r=0.762、0.632,P<0.05),血清sCD14水平与PCT水平呈正相关(r=0.694,P<0.05)。结论血清sTREM-1、sCD14和PCT对白内障术后发生眼内炎和前房积脓具有较高的诊断价值,联合检测的诊断效能明显高于单个指标检测,可用于辅助临床诊断。Objective To investigate the diagnostic value of serum soluble myeloid cell receptor-1(sTREM-1),soluble cell differentiation antigen 14(sCD14)and procalcitonin(PCT)in endophthalmitis and hypopyon in patients after cataract surgery.Methods A total of 98 patients(98 eyes)who developed endophthalmitis after cataract surgery in this hospital from January 2015 to December 2020 were selected as endophthalmitis group,among them,44 cases of hypopyon belong to the hypopyon group,and 54 cases of non-hypopyon belong to the non-hypopyon group.Selected 65 cases(65 eyes)without infection after cataract surgery in this hospital during the same period as the control group.The serum levels of sTREM-1,sCD14 and PCT in each group were detected by enzyme-linked immunosorbent assay at 1 d and 3 d after surgery.Compared the serum sTREM-1,sCD14 and PCT levels between endophthalmitis group and control group at 1 d and 3 d after surgery.Compared the serum sTREM-1,sCD14 and PCT levels in hypopyon group and non-hypopyon group at 3 d after surgery.Analyzed the diagnostic efficacy of serum sTREM-1,sCD14 and PCT detected alone and in combination for endophthalmitis and hypopyon at 3 d after surgery.Results The serum levels of sTREM-1,sCD14 and PCT in the endophthalmitis group at 3 d after surgery were significantly higher than those at 1 d after surgery and in the control group,and the differences were statistically significant(P<0.05).The combined detection of serum sTREM-1,sCD14 and PCT at 3 d after surgery had a sensitivity of 87.8%,a specificity of 90.8%,and an area under the curve(AUC)of 0.952 for the diagnosis of endophthalmitis after cataract surgery,which was significantly higher than the detection of each index alone(P<0.05).The levels of serum sTREM-1,sCD14 and PCT in the hypopyon group were significantly higher than those in the non-hypopyon group at 3 d after surgery,and the differences were statistically significant(P<0.05).The combined detection of serum sTREM-1,sCD14 and PCT at 3 d after surgery had a sensitivity of 84.1%,a spe

关 键 词：可溶性髓系细胞触发受体-1 可溶性白细胞分化抗原14 降钙素原 白内障 眼内炎 前房积脓 

分 类 号：R771[医药卫生—眼科]