慢性牙周炎与肺通气功能的相关性研究  

Correlation between chronic periodontitis and pulmonary ventilation function

作　　者：邱林 舒成军[2] 吴晓东[1] 徐世文[1] 方睿 Qiu Lin;Shu Chengjun;Wu Xiaodong;Xu Shiwen;Fang Rui(Department of Respiratory Medicine,Yuyao People's Hospital of Zhejiang Province,Yuyao 315400,Zhejiang Province,China;Department of Stomatology,Yuyao People's Hospital of Zhejiang Province,Yuyao 315400,Zhejiang Province,China)

机构地区：[1]余姚市人民医院呼吸内科,余姚315400 [2]余姚市人民医院口腔科,余姚315400

出　　处：《中国基层医药》2022年第7期961-966,共6页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省宁波市科技计划项目(2014C50085)。

摘　　要：目的探讨慢性牙周炎与肺通气功能的相关性。方法选择余姚市人民医院2014年6月至2019年12月收治的慢性牙周炎患者135例进行研究,按牙周炎病变程度分为A组45例(Ⅰ期,初期病损),B组45例(Ⅱ期,早期病损),C组45例(Ⅲ期,病变确立期),比较3组患者肺通气功能指标、血清白细胞介素6(IL-6)、白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)水平,分析牙周情况与肺通气功能指标之间的相关性。结果A组患者的探诊深度(PD)、临床附着丧失(CAL)、失牙数、影像学牙槽骨吸收水平分别为(1.67±0.65)mm、(2.48±0.44)mm、0颗、(1.38±0.23)mm,B组患者的PD、CAL、失牙数、影像学牙槽骨吸收水平分别为(2.05±0.30)mm、(4.04±0.97)mm、1颗、(3.37±0.73)mm,C组患者的PD、CAL、失牙数、影像学牙槽骨吸收水平分别为(2.23±0.47)mm、(5.17±0.75)mm、3颗、(6.48±0.62)mm,随着病情的加重,PD、CAL、失牙数、影像学牙槽骨吸收水平逐渐升高,C组患者的PD、CAL、影像学牙槽骨吸收水平均高于A组(t=4.68、20.75、51.74,均P<0.001)和B组(t=2.17、6.18、21.78,P=0.033、<0.001、<0.001),B组患者的PD、CAL、影像学牙槽骨吸收水平均高于A组患者(t=3.56、9.82、17.44,均P<0.001),3组失牙数比较差异无统计学意义(P>0.05);A组患者血清IL-6、IL-8、TNF-α水平分别为(11.28±4.26)ng/L、(7.48±1.97)ng/L、(14.59±2.11)ng/L,B组患者血清IL-6、IL-8、TNF-α水平分别为(17.09±4.91)ng/L、(10.82±2.10)ng/L、(19.95±4.48)ng/L,C组患者血清IL-6、IL-8、TNF-α水平分别为(26.47±5.86)ng/L、(15.06±2.75)ng/L、(33.76±6.30)ng/L,随着病情的加重,血清IL-6、IL-8、TNF-α水平逐渐升高,C组患者的IL-6、IL-8、TNF-α水平均高于A组(t=14.06、15.03、19.36,均P<0.001)和B组(t=8.23、8.22、11.98,均P<0.001),B组患者的IL-6、IL-8、TNF-α水平均高于A组(t=6.00、7.78、7.26,均P<0.001);A组患者第1秒最大呼气容积占预计值的百分比(FEV_(1)%pre)、第1秒最大呼气容积与用力�Objective To investigate the correlation between chronic periodontitis and pulmonary ventilation function.Methods A total of 135 patients with chronic periodontitis who received treatment in Yuyao People's Hospital of Zhejiang Province between June 2014 and December 2019 were included in this study.They were divided into group A(stage I,initial lesion,n=45),group B(stage II,early lesion,n=45),group C(stage III,confirmed lesion,n=45)according to the severity of periodontal lesion.Lung ventilation function indexes and serum levels of interleukin-6(IL-6),IL-8 and tumor necrosis factor-alpha(TNF-α)were compared among the three groups.The correlation between periodontal condition and lung ventilation function indexes was analyzed.Results Probing depth(PD),clinical attachment loss(CAL),number of missing teeth,alveolar bone resorption level were(1.67±0.65)mm,(2.48±0.44)mm,0 pieces,and(1.38±0.23)mm in group A,(2.05±0.30)mm,(4.04±0.97)mm,1 piece,(3.37±0.73)mm in group B,and(2.23±0.47)mm,(5.17±0.75)mm,3 pieces,(6.48±0.62)mm in group C.With the worsening of the disease,PD,CAL,number of missing teeth,and alveolar bone resorption level were gradually increased.PD,CAL and alveolar bone resorption level in group C were significantly higher than those in group A(t=4.68,20.75,51.74,all P<0.001)and group B(t=2.17,6.18,21.78,P=0.033,<0.001,<0.001).PD,CAL and alveolar bone resorption level in group B were significantly higher than those in group A(t=3.56,9.82,17.44,all P<0.001).There was no significant difference in the number of missing teeth(P>0.05).Serum IL-6,IL-8 and TNF-αlevels were(11.28±4.26)ng/L,(7.48±1.97)ng/L,(14.59±2.11)ng/L in group A,(17.09±4.91)ng/L,(10.82±2.10)ng/L,(19.95±4.48)ng/L in group B,and(26.47±5.86)ng/L,(15.06±2.75)ng/L,(33.76±6.30)ng/L]in group C.With the worsening of the disease,serum IL-6,IL-8 and TNF-αlevels were gradually increased.Serum IL-6,IL-8 and TNF-αlevels in group C were significantly higher than those in group A(t=14.06,15.03,19.36,P<0.001)and group B(t=8.23,8.22,11.98,all

关 键 词：慢性牙周炎 白细胞介素6 白细胞介素8 肿瘤坏死因子-Α 肺通气功能 相关性 

分 类 号：R781.42[医药卫生—口腔医学]