浓缩生长因子预防牙源性颌骨囊肿骨增量术后并发症的效果观察  

Efficacy of concentrated growth factor in the reduction of complications after bone augmentation during surgery for odontogenic maxillary cyst

作　　者：丁婕 王思明[1] Ding Jie;Wang Siming(Department of Stomatology,The Second People's Hospital of Lianyungang,Lianyungang 222000,Jiangsu Province,China)

机构地区：[1]连云港市第二人民医院口腔科,连云港222000

出　　处：《中国基层医药》2022年第7期971-974,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察浓缩生长因子(CGF)预防牙源性颌骨囊肿骨增量术后疼痛及肿胀的效果。方法选择2018年6月至2019年12月连云港市第二人民医院收治的牙源性颌骨囊肿需术中同期进行骨增量的患者16例为研究对象,采用随机数字表法分为两组,每组8例。观察组行CGF和骨替代品混合后上覆生物膜覆盖;对照组直接予以骨粉填充骨腔,上覆人工生物膜;比较分析两组患者术后肿胀、疼痛、瘢痕增生程度。疼痛参照视觉模拟评分法(VAS)测定,肿胀依据肿胀程度分为3个比较等级,瘢痕依照温哥华瘢痕量表(VSS)进行比较。数据采用SPSS 20.0软件进行统计分析。结果观察组1、2、3级肿胀所占百分比分别为62.5%(5/8)、37.5%(3/8)、0.0%(0/8),对照组分别为50.0%(4/8)、37.5%(3/8)、12.5%(1/8)(Z=-1.71,P>0.05);观察组、对照组肿胀持续时间分别为(3.8±0.9)d、(5.8±1.4)d,两组差异有统计学意义(t=6.88,P<0.05);观察组术后3 d、7 d、14 d的疼痛VAS评分分别为(2.21±0.25)分、(3.75±0.22)分、(0.57±0.13)分,对照组分别为(3.76±0.18)分、(2.38±0.26)分、(2.38±0.26)分,两组均差异有统计学意义(t_(3)=14.23、t7=11.29、t_(1)4=17.61,均P<0.001)。观察组术后1周、2周、4周温哥华瘢痕VSS评分分别为(4.26±0.26)分、(1.22±0.13)分、(2.47±0.11)分,对照组分别为(6.35±0.27)分、(4.47±0.73)分、(2.77±0.21)分,两组差异有统计学意义(t_(1)=15.77、t_(2)=2.67、t_(4)=3.58,均P<0.001)。结论CGF可以促进术后骨缺损修复及创面的愈合、减轻肿胀、疼痛、瘢痕等术后反应。Objective To investigate the efficacy of concentrated growth factor(CGF)in the reduction of pain and swelling after bone augmentation during surgery for odontogenic maxillary cyst.Methods Sixteen patients with odontogenic maxillary cysts who underwent bone augmentation during surgery between June 2018 and December 2019 were included in this study.They were randomly divided into two groups(n=8/group).In the observation group,CGF and bone substitutes were mixed and covered with biofilm.In the control group,bone powder was used to fill the bone cavity,and artificial biofilm was applied.Postoperative swelling,pain,and scar hyperplasia were compared between the two groups.Pain was rated according to visual analogue score.Swelling was divided into three grades according to the level of swelling.Scar was compared according to vancouver scar scale.Statistical analysis was performed using SPSS 20.0 software.Results The percentage of grade 1-3 swelling in the observation group were 62.5%(5/8),37.5%(3/8)and 0.0%(0/8),respectively,and they were 50.0%(4/8),37.5%(3/8),12.5%(1/8),respectively(Z=-1.71,P>0.05).There was significant difference in the duration of swelling between observation and control groups[(3.8±0.9)days vs.(5.8±1.4)days,t=6.88,P<0.05].At 3,7 and 14 days after surgery,visual analogue score was(2.21±0.25)points,(3.75±0.22)points and(0.57±0.13)points in the observation group and it was(3.76±0.18)points,(2.38±0.26)points,and(2.38±0.26)points in the control group(t=14.23,t=11.29,t=17.61,all P<0.001).At 1,2 and 4 weeks after surgery,vancouver scar scale score was(4.26±0.26)points,(1.22±0.13)points and(2.47±0.11)points in the observation group,and it was(6.35±0.27)points,(4.47±0.73)points and(2.77±0.21)points in the control group(t=15.77,t=2.67,t=3.58,P<0.001).Conclusion CGF can promote postoperative bone defect repair and wound healing and reduce postoperative swelling,pain and scar.

关 键 词：牙源性囊肿 生物膜 骨再生 浓缩生长因子 水肿 疼痛 手术后 瘢痕 

分 类 号：R782[医药卫生—口腔医学]