低能量激光治疗糜烂型口腔扁平苔藓43例疗效观察  

Efficacy of low-energy laser in the treatment of erosive oral lichen planus in 43 patients

作　　者：王玫[1] 毛玉虎[1] 郑海英 Wang Mei;Mao Yuhu;Zheng Haiying(Department of Stomatology,Shanxian Central Hospital,Heze 274300,Shandong Province,China;Department of Stomatology,Affiliated Hospital of Jining Medical University,Jining 272029,Shandong Province,China)

机构地区：[1]单县中心医院口腔科,菏泽274300 [2]济宁医学院附属医院口腔科,济宁272029

出　　处：《中国基层医药》2022年第7期975-979,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨低能量激光治疗糜烂型口腔扁平苔藓(OLP)的临床疗效及其对患者疼痛的影响。方法选取单县中心医院2018年2月至2020年1月治疗的糜烂型OLP患者86例,采用随机数字表法分为对照组、观察组各43例。对照组采用地塞米松局部注射,观察组采用半导体低能量激光照射治疗,两组疗程8周。评估两组治疗前后疼痛评分、体征评分,比较两组疗效;随访观察两组病损面积,统计治疗3、6个月后复发情况。结果治疗前,两组视觉模拟评分法(VAS)评分、体征评分均差异无统计学意义(均P>0.05);治疗7 d、14 d、28 d、56 d后,两组VAS评分、体征评分均较治疗前明显下降,观察组VAS评分、体征评分均明显低于对照组,均差异有统计学意义(均P<0.05)。观察组总有效率为93.02%(40/43),对照组为83.72%(36/43),两组差异无统计学意义(χ^(2)=1.81,P>0.05)。治疗前、治疗1个月后,两组病损面积均差异无统计学意义(均P>0.05),治疗3个月后、6个月后,观察组病损面积分别为(0.31±0.14)cm^(2)、(0.32±0.12)cm^(2),明显小于对照组的(0.42±0.18)cm^(2)、(0.48±0.19)cm^(2),均差异有统计学意义(t=3.16、4.67,均P<0.05)。观察组治疗3、6个月后复发率分别为2.33%(1/43)、13.95%(6/43),均明显低于对照组的13.95%(6/43)、37.21%(16/43),均差异有统计学意义(χ^(2)=3.89、6.11,均P<0.05)。结论低能量激光治疗糜烂型OLP与常规皮质类固醇比较短期疗效无明显差异,但低能量激光短期缓解患者疼痛的效果更明显,且可加速患者病损组织愈合,降低复发率。Objective To investigate the clinical efficacy of low-energy laser in the treatment of erosive oral lichen planus(OLP)and its effect on patients'pain.Methods Eighty-six patients with erosive OLP who were treated in Shanxian Central Hospital from February 2018 to January 2020 were included in this study.They were randomly divided into control and observation groups(n=43/group).The control group was treated by local injection of dexamethasone,and the observation group was treated with semiconductor low-energy laser irradiation.All patients were treated for 8 weeks.Pain scores and physical sign score before and after treatment were evaluated in each group.Therapeutic effects were compared between the two groups.Area of lesion was measured in each group.Recurrence of erosive OLP was calculated at 3 and 6 months after surgery.Results Before treatment,there were no significant differences in visual analogue scale(VAS)score and physical sign score between the two groups(both P>0.05).At 7,14,28 and 56 days after treatment,VAS score and physical sign score were significantly decreased in each group compared with those before treatment,and VAS score and physical sign score in the observation group were significantly lower than those in the control group(all P<0.05).Total response rate in the observation group was significantly higher than that in the control group[93.02%(40/43)vs.83.72%(36/43),χ^(2)=1.81,P>0.05).Before and 1 month after treatment,there was no significant difference in area of lesion between control and observation groups(both P>0.05).At 3 and 6 months after surgery,area of lesion in the observation group was(0.31±0.14)cm^(2) and(0.32±0.12)cm^(2),respectively,which were significantly smaller than those in the control group[(0.42±0.18)cm^(2),(0.48±0.19)cm^(2),t=3.16,4.67,both P<0.05).At 3 and 6 months after treatment,recurrence of erosive OLP in the observation group was 2.33%(1/43)and 13.95%(6/43),respectively,which were significantly lower than those in the control group[13.95%(6/43),37.21%(16/43),χ^

关 键 词：扁平苔藓 口腔 激光 半导体 口腔疾病 疼痛 疼痛测定 地塞米松 病灶面积 复发 

分 类 号：R781.5[医药卫生—口腔医学]