“Progressive motility”in elucidating novel genetic causes of male infertility  

作　　者：Feng Zhang 张锋(Institute of Reproduction and Development,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China;State Key Laboratory of Genetic Engineering,School of Life Sciences,Fudan University,Shanghai 200438,China;Human Phenome Institute,Zhangjiang Fudan International Innovation Center,Fudan University,Shanghai 201203,China)

机构地区：[1]Institute of Reproduction and Development,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China [2]State Key Laboratory of Genetic Engineering,School of Life Sciences,Fudan Universily,Shanghai 200438,China [3]Human Phenome Insttute,Zhangjiang Fudan International Innovation Center,Fudan University,Shanghai 201203,China

出　　处：《Asian Journal of Andrology》2022年第3期229-230,F0002,共3页亚洲男性学杂志（英文版）

摘　　要：Genetic factors play important roles in the etiology of male infertility.The routine clinical genetic testing for human spermatogenic failure is currently limited to abnormal karyotypes(e.g,47,XXY for Klinefelter syndrome)and Y chromosomal microdeletions.^(1)However,these chromosomal variants only account for approximately 20%of the infertile males with nonobstructive azoospermia.The vast majority of male infertile cases are genetically unexplained.With the recent advances in genomic technologies,the genome-wide dissections at the nucleotide resolution have been achieved,and the novel genetic factors involved in human male infertility have been continuously uncovered.Furthermore.

关 键 词：DATING CHROMOSOMAL ROUTINE 

分 类 号：R697[医药卫生—泌尿科学]