CHROMOSOMAL

作品数：213被引量：319H指数：9
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Chimeric RNA landscape in the placenta: A transcriptomic analysis revealing novel diagnostic biomarkers forpreeclampsia
《Genes & Diseases》2025年第1期80-84,共5页Jingjing Xu Xinrui Shi Shitong Lin Sandeep Singh Samuel Haddox Christopher Phung Tommy Manley Ningxi Huang Peng Wu Hui Li 
fund from the Chinese Study Council for the studying abroad program.
Chimeric RNAs,hybrid transcripts containing exons from two originally separate genes,have been extensively studied in various cancer types and non-cancerous tissues.1,2 The hybrid transcripts can arise through differe...
关键词：LANDSCAPE CHROMOSOMAL REVEALING 
Modern biology of extrachromosomal DNA: A decade-long voyage of discovery
《Cell Research》2025年第1期11-22,共12页Qing-Lin Yang Yipeng Xie Kailiang Qiao Jun Yi Stanley Lim Sihan Wu 
supported by the Cancer Prevention and Research Institute of Texas(CPRIT,RR210034);J.Y.S.L.is supported by the CPRIT Training Grant(RP210041);delivered as part of the eDyNAmiC team supported by the Cancer Grand Challenges partnership funded by Cancer Research UK(CGCATF-2021/100012 to P.S.M.,CGCATF-2021/100023 to S.W.);the National Cancer Institute(OT2CA278688 to P.S.M.,OT2CA278683 to S.W.).
Genomic instability is a hallmark of cancer and is a major driving force of tumorigenesis.A key manifestation of genomic instability is the formation of extrachromosomal DNAs(ecDNAs)—acentric,circular DNA molecules r...
关键词：CHROMOSOMAL ELEVATED driving 
Advances and perspectives in genetic expression and operation for the oleaginous yeast Yarrowia lipolytica
《Synthetic and Systems Biotechnology》2024年第4期618-626,共9页Mengchen Hu Jianyue Ge Yaru Jiang Xiaoman Sun Dongshen Guo Yang Gu 
supported by the National Natural Science Foundation of China 22108126 to Y.G.;The China Postdoctoral Science Foundation 2022M721362 to Y.G;the Natural Science Foundation of Jiangsu Province BK20210572 and BK20202002 and to Y.G.and H.H.,respectively.
The utilization of industrial biomanufacturing has emerged as a viable and sustainable alternative to fossil-based resources for producing functional chemicals.Moreover,advancements in synthetic biology have created n...
关键词：Yarrowia lipolytica Genetic expression and operation Genetic biosensors Genomic chromosomal operation 
Intergeneric chromosome-specific painting reveals differential chromosomal transmission from Tripidium arundinaceum in sugarcane progeny
《Journal of Integrative Agriculture》2024年第11期3751-3762,共12页Fan Yu Zehuai Yu Jin Chai Xikai Yu Chen Fu Xinwang Zhao Hailong Chang Jiawei Lei Baoshan Chen Wei Yao Muqing Zhang Jiayun Wu Qinnan Wang Zuhu Deng 
funded by the Central Government and Local Science and Technology Development Special Project,China(2022L3086);the Sugarcane Research Foundation of Guangxi University,China(2022GZB006);supported by the National Natural Science Foundation of China(31771863);the Academy of Sugarcane and Sugar Industry,Guangxi University,China(ASSI-2023009);an independent fund of Guangxi Key Laboratory of Sugarcane Biology,China(GXKLSCB-20190201);the China Agriculture Research System of MOF and MARA(CARS-20-1-5)。
Sugarcane has recently attracted increasing attention for its potential as a source of sugar and bioethanol,so increasing its yield is essential to ensure the sugar security and bioenergy production.Intergeneric hybri...
关键词：SUGARCANE Tripidium arundinaceum chromosome painting Oligo-FISH chromosomal transmission 
Determination of the chromosomal position effects for plug-and-play application in the Myxococcus xanthus chassis cells
《Synthetic and Systems Biotechnology》2024年第3期540-548,共9页Xin-jing Yue Jia-rui Wang Jun-ning Zhao Zhuo Pan Yue-zhong Li 
the National Key Research and Development Program of China(2021YFC2101000);the National Natural Science Foundation of China(32301220).
The chromosomal position effect can significantly affect the transgene expression,which may provide an efficient strategy for the inauguration of alien genes in new hosts,but has been less explored rationally.The bact...
关键词：Position effect High expression integration sites(HEISs) Myxococcus xanthus Tn-seq 
Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease被引量：1
《Signal Transduction and Targeted Therapy》2024年第7期2840-2842,共3页Jörg Fahrer 
supported by the German Research Foundation(INST 248/331-1 FUGG,FA1034/3-3,project number 258652740,FA 1034/6-1,project number 496762016,FA1034/8-1,project number 527664508);Kooperation Phytopharmaka GbR,Bonn,Germany(TU-KL#2);the European Partnership for the Assessment of Risks from Chemicals(PARC)under the Horizon Europe Research and Innovation Programme,Grant Agreement No.101057014.
A recent study by Adams and colleagues published in Nature unveiled more than one hundred genes that are involved in micronucleus formation,1 which is a biomarker for genomic instability and associated with aging,canc...
关键词：CHROMOSOMAL LINKING REPLICATION 
Inter3D:Capture of TAD Reorganization Endows Variant Patterns of Gene Transcription
《Genomics, Proteomics & Bioinformatics》2024年第3期69-84,共16页Tianyi Ding Shaliu Fu Xiaoyu Zhang Fan Yang Jixing Zhang Haowen Xu Jiaqi Yang Chaoqun Chen Yibing Shi Yiran Bai Wannian Li Xindi Chang Shanjin Wang Chao Zhang Qi Liu He Zhang 
supported by the National Natural Science Foundation of China(Grant Nos.82372705 and 31870748);the Shanghai Oriental Elite Project(Grant No.2000152009);the National Key R&D Program of China(Grant No.2017YFE0196300);the Shanghai Natural Science Foundation(Grant No.22ZR1466100);the Fundamental Research Funds for the Central Universities(Grant No.22120230292);the China Postdoctoral Science Foundation(Grant Nos.2023M742651 and GZC20231946);the Shuguang Project of Shanghai Municipal Education Commission and Shanghai Education Development Foundation(Grant No.17SG19);the Outstanding Yong Medical Scholar of Shanghai Municipal Commission of Health and Family Planning(Grant No.2017YQ067);the Outstanding Yong Scholar Grant of Tongji University(Grant No.PA2019000239);the Startup Funding of Frontier Science Research Center for Stem Cells&Shanghai East Hospital of Tongji University(Grant No.DFRC2019003),China.
Topologically associating domain(TAD)reorganization commonly occurs in the cell nucleus and contributes to gene activation and inhibition through the separation or fusion of adjacent TADs.However,functional genes impa...
关键词：Topologically associating domain Inter3D Chromosomal loop Gene transcription Cancer 
Chromosomal-level genome and metabolome analyses of highly heterozygous allohexaploid Dendrocalamus brandisii elucidate shoot quality and developmental characteristics被引量：1
《Journal of Integrative Plant Biology》2024年第6期1087-1105,共19页Jutang Jiang Zeyu Zhang Yucong Bai Xiaojing Wang Yuping Dou Ruiman Geng Chongyang Wu Hangxiao Zhang Cunfu Lu Lianfeng Gu Jian Gao 
supported by the National Key Research and Development Program of China(2021YFD2200505,2018YFD0600101);the National Natural Science Foundation of China(32071849)。
Dendrocalamus brandisii(Munro)Kurz is a sympodial bamboo species with inimitable taste and flavorful shoots.Its rapid growth and use as high-quality material make this bamboo species highly valued for both food proces...
关键词：bamboo shoots Dendrocalamus brandisii(Munro)Kurz flavonoid GENOME lignin 
High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality:A case report
《World Journal of Clinical Cases》2024年第18期3539-3547,共9页Kai-Cheng Zhang Shao-Yin Chu Dah-Ching Ding 
BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnorm...
关键词：High-grade serous carcinoma Fallopian tube Young age Chromosomal abnormality Mental retardation AGING Case report 
Mutation Studies of 31 Highly Mutated Y-chromosomal Short Tandem Repeat Systems in the Han Population of Northern China
《Journal of Forensic Science and Medicine》2024年第2期155-162,共8页Shicheng Hao Jinghan Chen Hang He Li Yuan 
supported by the Fundamental Research Funds for the Central Universities.In addition,this study was also supported by opening research grants from Shanghai Key Lab of Forensic Medicine,Key Lab of Forensic Science,the Ministry of Justice,PR.China(Academy of Forensic Science)(No.KF202111).
A six-color fluorescent multiplex amplification system for 31 Y-chromosomal short tandem repeats(Y-STRs)(DYS19,DYS390,DYS391,DYF399S1,DYF404S1,DYS439,DYS444,DYS449,DYS452,DYS456,DYS458,DYS460,DYS481,DYS508,DYS513,DYS5...
关键词：Forensic genetics mutation rate rapidly mutating Y-chromosomal short tandem repeat 
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