Chimeric RNA landscape in the placenta: A transcriptomic analysis revealing novel diagnostic biomarkers forpreeclampsia  

作　　者：Jingjing Xu Xinrui Shi Shitong Lin Sandeep Singh Samuel Haddox Christopher Phung Tommy Manley Ningxi Huang Peng Wu Hui Li 

机构地区：[1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [2]Department of Biochemistry and Molecular Genetics,University of Virginia,Charlottesville,VA 22908,USA [3]Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [4]Cancer Biology Research Center (Key Laboratory of the Ministry of Education),Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [5]Department of Pathology,University of Virginia,Charlottesville,VA 22908,USA [6]Department of Biomedical Engineering,University of Virginia,Charlottesville,VA 22908,USA [7]Computational Toxicology Facility,CSIR-Indian Institute of Toxicology Research,Lucknow,Uttar Pradesh,226001,India

出　　处：《Genes & Diseases》2025年第1期80-84,共5页基因与疾病(英文)

基　　金：fund from the Chinese Study Council for the studying abroad program.

摘　　要：Chimeric RNAs,hybrid transcripts containing exons from two originally separate genes,have been extensively studied in various cancer types and non-cancerous tissues.1,2 The hybrid transcripts can arise through different mechanisms,such as chromosomal rearrangements,trans-splicing events,or read-through transcription.The investigation into chimeric RNA landscape across various cancer types as well as in normal physiology processes has highlighted their potential roles in regulating gene expression and cellular functions.

关 键 词：LANDSCAPE CHROMOSOMAL REVEALING 

分 类 号：R73[医药卫生—肿瘤]