Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease  

作　　者：Jörg Fahrer 

机构地区：[1]Division of Food Chemistry and Toxicology,Department of Chemistry,RPTU Kaiserslautern-Landau,67663 Kaiserslautern,Germany

出　　处：《Signal Transduction and Targeted Therapy》2024年第7期2840-2842,共3页信号转导与靶向治疗（英文）

基　　金：supported by the German Research Foundation(INST 248/331-1 FUGG,FA1034/3-3,project number 258652740,FA 1034/6-1,project number 496762016,FA1034/8-1,project number 527664508);Kooperation Phytopharmaka GbR,Bonn,Germany(TU-KL#2);the European Partnership for the Assessment of Risks from Chemicals(PARC)under the Horizon Europe Research and Innovation Programme,Grant Agreement No.101057014.

摘　　要：A recent study by Adams and colleagues published in Nature unveiled more than one hundred genes that are involved in micronucleus formation,1 which is a biomarker for genomic instability and associated with aging,cancer,and other disorders.2 As an outstanding achievement,the authors identified DSCC1(DNA Replication And Sister Chromatid Cohesion 1)as a critical gene protecting against early developmental defects,genomic instability,reduced proliferative capacity,cohesinopathy-related phenotypes,and tumor development in vivo.

关 键 词：CHROMOSOMAL LINKING REPLICATION 

分 类 号：R394[医药卫生—医学遗传学]