根治性前列腺切除术后不良病理特征患者的放疗选择  

Adjuvant or salvage radiotherapy in patients with adverse pathological features after radical prostatectomy

作　　者：赵峻樑 赵迪威 刘洋 何立儒[2] 周芳坚[1] 李永红[1] Zhao Junliang;Zhao Diwei;Liu Yang;He Liru;Zhou Fangjian;Li Yonghong(Department of Urology,Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,China;Department of Radiation Oncology,Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,China)

机构地区：[1]中山大学肿瘤防治中心泌尿外科,华南肿瘤学国家重点实验室,肿瘤医学协同创新中心,广州510060 [2]中山大学肿瘤防治中心放疗科,华南肿瘤学国家重点实验室,肿瘤医学协同创新中心,广州510060

出　　处：《中华泌尿外科杂志》2022年第7期555-558,共4页Chinese Journal of Urology

摘　　要：根治性前列腺切除术(RP)是局限期前列腺癌常用的治疗方法。RP后伴有不良病理特征(APF)的患者,选择辅助放疗还是挽救性放疗(SRT)尚存在争议。近年研究结果显示,部分患者采取早期挽救性放疗(ESRT)与辅助放疗的控瘤效果相当,且可以减少过度治疗。列线图和基因分类器可预测RP后复发风险,有助于个体化选择辅助放疗或ESRT。PSMA PET/CT在生化复发后检测远处转移病灶的敏感性较高,有助于决定是否实施SRT。Radical prostatectomy(RP)was commonly used in localized prostate cancer.For patients with adverse pathological features(APF)after RP,it was controversial about choosing adjuvant radiotherapy or salvage radiotherapy(SRT).Recent studies have found that early salvage radiotherapy(ESRT)had both the same cancer control and reduced overtreatment compared to adjuvant radiotherapy.Nomogram and Gene Classifier(GC)could predict the risk of recurrence after RP and contribute to choose adjuvant radiotherapy or ESRT.PSMA PET/CT was more sensitive to detect distant metastasis after biochemical recurrence,which was helpful to decide whether to implement SRT.

关 键 词：前列腺肿瘤 癌 根治性前列腺切除术 不良病理特征 辅助放疗 挽救性放疗 

分 类 号：R737.25[医药卫生—肿瘤]