脑胶质瘤患者手术治疗预后不良的相关因素分析  

Analysis of related factors of poor prognosis in patients with glioma after surgical treatment

作　　者：李涛[1] 翟景光[1] 刘晓[1] Li Tao;Qu Jingguang;Liu Xiao(Neurosurgery department,Yongcheng people's hospital,Yongcheng,Henan,476600,China.)

机构地区：[1]永城市人民医院神经外科,河南永城476600

出　　处：《齐齐哈尔医学院学报》2022年第11期1047-1051,共5页Journal of Qiqihar Medical University

摘　　要：目的分析脑胶质瘤患者手术切除术后预后不良的影响因素。方法选择2018年10月—2020年9月本院收治的107例脑胶质瘤患者作为研究对象,全部患者均经手术切除治疗,并随访1年;根据患者随访1年时生存情况,将患者分为预后良好组(生存)与预后不良组(病死);设计患者基线资料调查表,比较两组患者基线资料、实验室指标等,分析脑胶质瘤患者手术治疗预后不良的影响因素。结果107例脑胶质瘤患者术后1年预后不良74例,预后不良发生率为69.16%(74/107);预后不良组WHO分级、非全切除术占比高于预后良好组,术前血清TGF-β水平高于预后良好组,术前KPS评分、IL-18水平低于预后良好组,差异有统计学意义(P<0.05);组间其他资料比较差异无统计学意义(P>0.05);经logistic回归分析,结果显示,WHO分级高、非全切手术、术前血清TGF-β水平高是脑胶质瘤患者手术治疗预后不良的危险因素(OR>1,P<0.05),术前KPS评分、IL-18水平高是其保护因素(OR<1,P<0.05)。结论脑胶质瘤患者手术治疗预后不良可能受患者WHO分级、手术方式、术前KPS评分、术前血清TGF-β、IL-18水平的影响。Objective To analyze the influencing factors of poor prognosis in patients suffered with glioma and received surgical resection.Methods 107 patients suffered with glioma those were treated in the hospital from October 2018 to September 2020 were selected as the research objects,all patients underwent surgical resection and were followed up for 1 year.According to the survival of patients at the end of 1-year follow-up,they were divided into good prognosis group(survival)and poor prognosis group(death from illness).A baseline data questionnaire of patients was designed,the baseline data and laboratory indexes of patients in the two groups were compared,the influencing factors of poor prognosis in patients suffered with glioma and received surgical treatment were analyzed.Results One year after operation,74 of 107 patients with glioma had a poor prognosis,the incidence of poor prognosis was 69.16%(74/107).Compared with the good prognosis group,the WHO grade and the proportion of incomplete resection in the poor prognosis group were higher,the preoperative serum TGF-βlevel was higher and the preoperative KPS score and IL-18 level were lower,with statistical significant differences(P<0.05).There was no statistical significant difference in comparison of other data between groups(P>0.05).The results of Logistic regression analysis showed that,high WHO grade,non total resection and high preoperative serum TGF level were risk factors for poor prognosis of patients with glioma after surgical treatment(OR>1,P<0.05);preoperative KPS score and high level of IL-18 were its protective factors(OR<1,P<0.05).Conclusions The poor prognosis of patients suffered with glioma after surgical treatment may be affected by WHO grade,surgical method,preoperative KPS score,preoperative serum TGF and IL-18 levels.

关 键 词：脑胶质瘤 脑胶质瘤切除术 预后 影响因素 

分 类 号：R739.41[医药卫生—肿瘤]