Tyramine-enhanced zwitterion hyaluronan hydrogel coating for anti-fouling and anti-thrombosis  

作　　者：GUO ZhiCheng YAO MengMeng SUN Hong SHI MingYue DONG XiaoRu HE ShaoShuai GUO BingYan YAO FangLian ZHANG Hong LI JunJie 

机构地区：[1]School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China [2]School of Basic Medical Sciences,North China University of Science and Technology,Tangshan 063210,China [3]Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education),Tianjin University,Tianjin 300350,China [4]School of Materials Science and Engineering,East China Jiaotong University,Nanchang 330013,China

出　　处：《Science China(Technological Sciences)》2022年第8期1828-1844,共17页中国科学（技术科学英文版）

基　　金：supported by the National Key Research and Development Program of China (Grant No. 2018YFC1105500);the National Natural Science Foundation of China (Grant Nos. U20A20261,31870948,31971250,and 52073205);the Natural Science Foundation of Tianjin (Grant Nos. 20JCYBJC00660 and 21JCYBJC00560)。

摘　　要：Zwitterions have aroused much interest to endow implantable medical devices with anti-fouling and anti-thrombosis performance,due to their ability to form a hydrated layer that can provide a good barrier against protein and cell adhesion. Herein,tyramine modified sulfobetaine-derived sodium hyaluronan(HST) hydrogel coating was fabricated, in which hyaluronan(HA)was used as polysaccharide skeleton to graft zwitterionic sulfobetaine, and tyramine was introduced as crosslinker to construct both the network of hydrogel and a strong covalent bond between coating and substrate. Hydrogel coating was prepared by spin coating or painting HST prepolymer solution under ultraviolet light irradiation. The obtained HST hydrogel coating shows good stability. Moreover, in addition to its outstanding anti-fouling performance and good biocompatibility, it can effectively prevent thrombosis in blood circulation ex vivo. This work offers a universal strategy to prepare a high-performance anti-fouling and antithrombosis coating, which is expected to promote the development of functional coatings for biomedical materials.

关 键 词：HYALURONAN ZWITTERION TYRAMINE hydrogel coating ANTI-FOULING anti-thrombosis 

分 类 号：TB306[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]