超声影像纹理分析鉴别诊断腮腺混合瘤和腺淋巴瘤的价值  

The value of ultrasonic images texture analysis in differential diagnosis of parotid pleomorphic adenoma and adenolymphoma

作　　者：韩文[1] 李卫民 凌莉[1] 陈伟 HAN Wen;LI Weimin;LING Li;CHEN Wei(Department of Ultrasound,People's Hospital of Suzhou National New Hi-tech Industrial,Suzhou Jiangsu 215129;Department of Ultrasound,Affiliated Hospital of Jiangnan University,Wuxi Jiangsu 214000,China)

机构地区：[1]苏州高新区人民医院超声科,江苏苏州215129 [2]江南大学附属医院超声科,江苏无锡214000

出　　处：《江苏大学学报（医学版）》2022年第5期409-414,共6页Journal of Jiangsu University：Medicine Edition

基　　金：苏州高新区医疗卫生科技计划项目(SGY2021B01)。

摘　　要：目的:探讨超声影像纹理分析鉴别诊断腮腺混合瘤和腺淋巴瘤的价值。方法:选取43个腮腺混合瘤和54个腺淋巴瘤,对比分析两者的常规超声特征,并将超声二维影像导入MaZda软件中,手动勾画病变的感兴趣区,分别选择交互信息(mutual information,MI),分类错误概率联合平均相关系数(probability of classification error and average correlation coefficients,POE+ACC),Fisher系数以及三种方法的联合(Fisher+POE+ACC+MI)提取最具鉴别价值的纹理特征参数,并构建人工神经网络(artificial neural network,ANN)模型。以病理结果为标准,对比分析纹理分析和超声医师评估的误判率。结果:腮腺腺淋巴瘤患者的年龄以及男性患者的比例高于腮腺混合瘤患者,差异具有统计学意义(P<0.001)。常规超声特征中,两者在囊性变和血流丰富程度之间具有统计学差异(P<0.001或P<0.05)。MaZda软件提取的30组纹理参数中,共8组具有统计学差异(P均<0.05)。纹理方法的评估结果中,MI的总误判率为53.61%(52/97),POE+ACC为44.32%(43/97),Fisher系数为21.65%(21/97),三种方法联合为17.53%(17/97);且三种方法联合的总误判率明显低于超声医师的总误判率(29.90%,29/97),差异有统计学意义(χ^(2)=4.103,P<0.05)。结论:超声影像纹理分析对腮腺混合瘤和腺淋巴瘤的鉴别诊断具有一定的价值。Objective:To investigate the value of ultrasonic images texture analysis in differential diagnosis of parotid pleomorphic adenoma and adenolymphoma.Methods:A total of 43 parotid pleomorphic adenomas and 54 adenolymphomas were selected.The ultrasonic images were imported into Mazda 4.6 software and ROIs were manually drawed.The optimum texture parameters were selected through mutual information(MI),Fisher coefficient,probability of classification error and average correction coefficient(POE+ACC)and the combination of three methods(Fisher+POE+ACC+MI),respectively.The model of artificial neural network was built.The assessment results of texture analysis and ultrasonic doctors were compared with the pathology.And misdiagnostic rates were analyzed between texture analysis and ultrasonic doctors.Results:The age and proportion of male in patients with parotid adenolymphoma were higher than those with parotid pleomorphic adenoma,there were statistically difference(P<0.001).In ultrasonic features,there were statistical difference between cystic degeneration and blood flow in two groups(P<0.001 or P<0.05).Among the 30 groups of texture parameters extracted by Mazda,there were 8 groups with statistical differences(all P<0.05).The misdiagnostic rates of MI,POE+ACC,Fisher and Fisher+POE+ACC+MI were 53.61%(52/97),44.32%(43/97),21.65%(21/97),17.53%(17/97),respectively.Furthermore,the misjudgment rate of the combination of three methods was lower than that of the ultrasound doctors(29.90%,29/97),there was statistical differences(χ^(2)=4.103,P<0.05).Conclusion:Ultrasonic images texture analysis can be used to differentiate parotid pleomorphic adenoma and adenolymphoma.

关 键 词：超声影像 纹理分析 腮腺混合瘤 腮腺腺淋巴瘤 

分 类 号：R739.8[医药卫生—肿瘤] R445.1[医药卫生—临床医学]