阿尔茨海默病患者口腔微生物及局部炎症因子表达变化的研究  

Study on the Change of Oral Microorganisms and Local Inflammatory Factors Expression of Patients with Alzheimer’s Disease

作　　者：陈玉英 郭玲[1] CHEN Yuying;GUO Ling(South Hospital of Fujian Provincial Hospital,Fuzhou 350001,China;不详)

机构地区：[1]福建省立医院南院,福建福州350001

出　　处：《中国医学创新》2022年第23期56-59,共4页Medical Innovation of China

摘　　要：目的:探究及观察阿尔茨海默病患者口腔微生物及局部炎症因子的表达。方法:选取2019年3月-2021年2月福建省立医院南院收治的90例阿尔茨海默病患者为观察组,选取同时期的90例非神经系统疾病患者为对照组。比较两组牙龈卟啉单胞菌、齿垢密螺旋体检出率及其Ct值、脑脊液及龈沟液的炎症因子[白介素-1β(IL-1β)、白介素-6(IL-6)]。比较观察组中不同严重程度患者的上述指标,采用Pearson相关性分析牙龈卟啉单胞菌、齿垢密螺旋体Ct值与脑脊液及龈沟液炎症因子的关系,Spearman秩相关分析上述指标与阿尔茨海默病严重程度的关系。结果:观察组牙龈卟啉单胞菌、齿垢密螺旋体检出率及Ct值均高于对照组,差异均有统计学意义(P<0.05)。观察组重度患者的牙龈卟啉单胞菌、齿垢密螺旋体的检出率及Ct值均高于轻度和中度患者,且中度均高于轻度患者,差异均有统计学意义(P<0.05)。观察组脑脊液及龈沟液的IL-1β和IL-6均高于对照组,差异均有统计学意义(P<0.05)。Pearson相关性分析显示,观察组检出牙龈卟啉单胞菌、齿垢密螺旋体患者的Ct值与脑脊液及龈沟液炎症因子均呈正相关(P<0.05)。Spearman秩相关分析显示,观察组检出牙龈卟啉单胞菌、齿垢密螺旋体患者的Ct值、脑脊液及龈沟液炎症因子均与阿尔茨海默病严重程度均呈正相关(P<0.05)。结论:阿尔茨海默病患者口腔微生物及局部炎症因子显著异常,且与阿尔茨海默病严重程度有密切的关系,在阿尔茨海默病的诊治与防控中具有较高的检测意义。Objective:To investigate and observe the change situation of oral microorganisms and local inflammatory factors expression of patients with Alzheimer’s disease.Method:A total of 90 patients with Alzheimer’s disease in South Hospital of Fujian Provincial Hospital from March 2019 to February 2021 were chosen as the observation group,90 patients with non nervous system diseases at the same time were chosen as the control group.The detection rates of porphyromonas gingivalis and treponema alveolaris and their Ct values,the inflammatory factors of cerebrospinal fluid and gingival crevicular fluid[interleukin-1β(IL-1β),interleukin-6(IL-6)]were compared between two groups.The above indexes were compared among the observation group with different severity.Pearson correlation analysis was used to analyze the relationship between Porphyromonas gingivalis,Treponema alveolaris Ct values and inflammatory factors of cerebrospinal fluid and gingival crevicular fluid,and Spearman rank correlation analysis was used to analyze the relationship between the above indexes and the severity of Alzheimer’s disease.Result:The detection rates and Ct values of Porphyromonas gingivalis and Treponema alveolaris in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The detection rates and Ct values of Porphyromonas gingivalis and Treponema alveolaris in severe patients were higher than those in mild and moderate patients,and those in moderate patients were higher than those in mild patients,the differences were statistically significant(P<0.05).The levels of IL-1βand IL-6 in cerebrospinal fluid and gingival crevicular fluid in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Pearson correlation analysis showed that Ct values of patients with Porphyromonas gingivalis and Treponema alveolaris were positively correlated with in cerebrospinal fluid and gingival in the observation group inflammatory

关 键 词：阿尔茨海默病 口腔微生物 局部炎症因子 

分 类 号：R749.16[医药卫生—神经病学与精神病学]