92例低频电子脉冲睡眠仪治疗失眠的临床观察  

Clinical observation of 92 patients with insomnia treated by low frequency electronic pulse sleep apparatus

作　　者：黄丹霞[1] 李润[1] 陈莹[1] 周伟凌 李璇[1] HUANG Danxia;LI Run;CHEN Ying;ZHOU Weiling;LI Xuan(The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510000,China)

机构地区：[1]广州医科大学附属第一医院,广东广州510000

出　　处：《现代医院》2022年第7期1146-1148,共3页Modern Hospitals

基　　金：广东省卫生健康委员会指令性课题;广东省医学科学技术研究基金项目(C201913)。

摘　　要：目的研究92例低频电子脉冲睡眠仪治疗失眠的临床疗效。方法选取2019年7月-2021年12月门诊确诊的92例失眠症患者纳入研究对象,以随机数表法分为观察组(n=46)与对照组(n=46),对照组患者口服唑吡坦,5mg/次,每晚1次。观察组在对照组基础上给予低频电子脉冲睡眠仪治疗,1次/天。两组均连续治疗1个月。比较两组临床疗效,治疗前后匹兹堡睡眠质量指数(PSQI)、多导睡眠图监测指标(总睡眠时间、睡眠效率、睡眠潜伏期、醒觉次数)、5-羟色氨酸(5-HT)、多巴胺(DA)、去甲肾上腺素(NE)水平。结果观察组总有效率显著高于对照组(P<0.05);两组治疗前PSQI各维度评分及总分比较无差异(P>0.05);两组治疗后与治疗前相比PSQI各维度评分及总分显著降低(P<0.05);观察组治疗后PSQI各维度评分及总分显著均低于对照组(P<0.05);两组治疗前总睡眠时间、睡眠效率、睡眠潜伏期、醒觉次数比较无差异(P>0.05);两组治疗后与治疗前相比总睡眠时间、睡眠效率显著升高,睡眠潜伏期、醒觉次数显著降低(P<0.05);观察组治疗后总睡眠时间、睡眠效率显著高于对照组,睡眠潜伏期、醒觉次数低于对照组(P<0.05);两组治疗前5-HT、DA、NE比较无差异(P>0.05);两组治疗后与治疗前相比5-HT、DA显著升高,NE显著降低(P<0.05);观察组治疗后5-HT、DA显著高于对照组,NE低于对照组(P<0.05)。结论低频电子脉冲睡眠仪治疗失眠疗效确切,可改善睡眠质量及5-HT、DA、NE水平,值得应用。Objective To study the clinical effect of 92 patients with insomnia treated by low frequency electronic pulse sleep apparatus.Methods From July 2019 to December 2021,92 patients with insomnia diagnosed in the outpatient clinic were selected and included in the study,and the observation group(n=46)and the control group(n=46)were divided into observation group(n=46)and control group(n=46)by random number table method,and the control group patients took zolpidem orally 5 mg/time once a night.The observation group was treated with a low-frequency electronic pulse sleep apparatus on the basis of the control group,1 time/day.Both groups were treated continuously for 1 month.Comparing the clinical efficacy of the two groups,Pittsburgh Sleep Quality Index(PSQI),polysomnography monitoring indicators(total sleep time,sleep efficiency,sleep latency,number of awakenings),serotryptophan(5-HT),dopamine(DA),norepinephrine(NE)levels before and after treatment were compared.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the score and total score of PSQI before treatment were no different(P>0.05);the score and total score of PSQI were significantly lower(P<0.05)after treatment and pre-treatment in the two groups;the score and total score of PSQI after treatment were significantly lower than those in the control group(P<0.05);the total sleep time,sleep efficiency,sleep latency before treatment were significantly lower than those in the control group(P<0.05);the total sleep time,sleep efficiency,sleep latency,There was no difference in the number of awakenings(P>0.05);the total sleep time and sleep efficiency were significantly increased after treatment and before treatment,and the sleep latency and number of awakenings were significantly reduced(P<0.05);the total sleep time and sleep efficiency after treatment in the observation group were significantly higher than those in the control group,and the sleep latency and awakening times were lower than those in

关 键 词：低频电子脉冲睡眠仪 失眠症 匹兹堡睡眠质量指数 5-羟色氨酸 

分 类 号：R749.05[医药卫生—神经病学与精神病学]