γ-丁内酯戒断后致严重横纹肌溶解1例  

A case of severe rhabdomyolysis afterγ-butyrolactone withdrawal

作　　者：汪文杰[1] 鲁厚清[1] Wang Wenjie;Lu Houqing(Intensive Care Unit,Tongling People's Hospital,Tongling 244000,China)

机构地区：[1]铜陵市人民医院重症医学科,铜陵244000

出　　处：《中华劳动卫生职业病杂志》2022年第7期537-538,共2页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：安徽省"十三五"临床重点专科建设计划项目。

摘　　要：γ-丁内酯为无色透明液体,用于生产环丙胺、吡咯烷酮等药品,也用作工业的溶剂、稀释剂、固化剂等,被列为第三类易制毒化学品管控。临床上接触γ-丁内酯较少,对其戒断反应研究也不充分。本文报道1例γ-丁内酯戒断反应患者出现严重横纹肌溶解,危及生命;经过积极治疗,患者最终康复。总结γ-丁内酯戒断反应的临床特征及治疗方式,提示γ-丁内酯可能出现严重的戒断反应。γ-butyrolactone is a colorless transparent liquid used in the production of drugs such as cyclopropylamine and pyrrolidone,and is also used as an industrial solvent,diluent,curing agent,etc.,and is listed as the third category of precursor chemicals control.There is less clinical exposure toγ-butyrolactone and insufficient studies on its withdrawal response.This article reports a case of severe life-threatening rhabdomyolysis in a patient withγ-butyrolactone withdrawal.After active treatment,the patient eventually recovered.The clinical characteristics and treatment methods ofγ-butyrolactone withdrawal reaction were summarized,suggesting that severe withdrawal reaction may occur inγ-butyrolactone.

关 键 词：物质戒断综合征 Γ-丁内酯 横纹肌溶解 

分 类 号：R749.61[医药卫生—神经病学与精神病学] R685.5[医药卫生—临床医学]