声门上型喉癌患者血清LncRNA PCAT1、miR-210表达与预后的关系  

The correlation between the expressions of serum LncRNA PCAT1, miR-210 and postoperative recurrence of early supraglottic laryngeal carcinoma

作　　者：延青[1] 杨花荣[1] 王娜娜[1] YAN Qing;YANG Huarong;WANG Nana(Department of rhinolaryngology,Affiliated Hospital of Yan'an University,Yan'an 716000,Shaanxi)

机构地区：[1]延安大学附属医院鼻咽喉科,陕西延安716000

出　　处：《中国中西医结合耳鼻咽喉科杂志》2022年第4期250-254,共5页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的探讨血清长链非编码RNA前列腺癌相关转录因子1(LncRNA PCAT1)、微小RNA-210(miR-210)表达与早期声门上型喉癌术后复发的相关性。方法选取2013年12月~2017年12月于本院就诊的早期声门上型喉癌患者120例为观察组,术后随访24个月,复发患者21例为复发组,未复发患者99例为非复发组,另选择同期于本院进行体检的健康者120例为对照组。采用实时荧光定量PCR(qRT-PCR)法检测血清LncRNA PCAT1、miR-210水平;采用Logistic回归分析影响早期声门上型喉癌患者术后复发的危险因素;采用ROC曲线分析血清LncRNA PCAT1、miR-210对早期声门上型喉癌患者术后复发的预测价值。结果观察组血清LncRNA PCAT1水平显著高于对照组(P<0.05),血清miR-210水平显著低于对照组(P<0.05);复发组血清LncRNA PCAT1水平显著高于非复发组(P<0.05),血清miR-210水平显著低于非复发组(P<0.05)。Logistic回归分析结果显示,T分期为T2期、血清LncRNA PCAT1高表达、miR-210低表达均是影响早期声门上型喉癌患者术后复发的独立危险因素(P<0.05)。ROC曲线分析结果显示,血清LncRNA PCAT1预测早期声门上型喉癌患者术后复发的曲线下面积为0.899,截断值为1.601,敏感度为81.0%,特异性为98.0%。血清miR-210预测早期声门上型喉癌患者术后复发的曲线下面积为0.764,截断值为0.902,敏感度为90.5%,特异性为60.6%。血清LncRNA PCAT1、miR-210联合预测早期声门上型喉癌患者术后复发的曲线下面积为0.925,敏感度为81.0%,特异性为99.0%。结论早期声门上型喉癌患者血清LncRNA PCAT1水平升高,血清miR-210水平降低,均是影响早期声门上型喉癌患者术后复发的独立危险因素,对评估早期声门上型喉癌患者术后复发具有一定价值。Objective To investigate the correlations between the expressions of serum long non-coding RNA prostate cancer related transcription factor 1(LncRNA PCAT1),microRNA-210(miR-210)and the postoperative recurrence of early supraglottic laryngeal carcinoma.Methods From December 2013 to December 2017,120 patients with early supraglottic carcinoma were selected as the observation group,and after 24 months of follow-up,21 patients with recurrence were in the recurrence group and 99 patients without recurrence were in the non recurrence group,in addition,120 healthy people who had physical examination in our hospital at the same time were selected as the control group.The levels of serum LncRNA PCAT1 and miR-210 were detected by real-time fluorescent quantitative PCR(qRT-PCR);Logistic regression analysis was used to analyze the risk factors of postoperative recurrence in patients with early supraglottic carcinoma;and ROC curve was used to analyze the predictive values of serum LncRNA PCAT1 and miR-210 for postoperative recurrence of early supraglottic carcinoma.Results The level of serum LncRNA PCAT1 in the observation group was significantly higher than that in the control group(P<0.05),and the level of serum miR-210 was significantly lower than that in the control group(P<0.05);the level of serum LncRNA PCAT1 in the recurrence group was significantly higher than that in the non recurrence group(P<0.05),and the level of serum miR-210 was significantly lower than that in the non recurrence group(P<0.05).Logistic regression analysis showed that T2 stage,high expression of serum LncRNA PCAT1 and low expression of miR-210 were independent risk factors for postoperative recurrence of early supraglottic carcinoma(P<0.05).ROC curve analysis showed that the area under the curve of serum LncRNA PCAT1 in predicting the recurrence of early supraglottic carcinoma was 0.899,the cutoff value was 1.601,the sensitivity was 81.0%,and the specificity was 98.0%;the area under the curve of serum miR-210 predicting the recurrence of early su

关 键 词：声门上型喉癌 长链非编码RNA前列腺癌相关转录因子1 微小RNA-210 预后 相关性 

分 类 号：R739.65[医药卫生—肿瘤]