恶性肿瘤家族史对鼻咽癌预后的影响  

Influence of family history of malignant tumor on prognosis of nasopharyngeal carcinoma

作　　者：郑露 刘锦全 方楠 杨展昕 齐斌 尹文晶 ZHENG Lu;LIU Jinquan;FANG Nan;YANG Zhanxin;QI Bin;YIN Wenjing(Department of Radiotherapy,Cancer Hospital Affiliated to Guangzhou Medical University,Guangzhou,Guangdong 510145,China)

机构地区：[1]广州医科大学附属肿瘤医院放疗科,广东广州510145

出　　处：《现代医药卫生》2022年第16期2724-2729,共6页Journal of Modern Medicine & Health

基　　金：吴阶平医学基金会项目(320.6750.2020-13-11)。

摘　　要：目的探讨恶性肿瘤家族史对鼻咽癌患者预后的影响。方法选取2010年2月至2016年10月该院鼻咽癌患者1211例,将其分为无恶性肿瘤家族史组(A组)和有恶性肿瘤家族史组(B组)。比较2组恶性肿瘤家族史情况、基线特征及生存情况,同时对预后影响因素进行分析。结果1211例患者中,215例(17.8%)有恶性肿瘤家族史。2组性别、吸烟史、饮酒史、N分期、化疗模式、放疗技术比较,差异无统计学意义(P>0.05),而年龄、T分期、临床分期比较,差异有统计学意义(P<0.05)。2组总生存率(OS)、无局部区域复发生存率(LRRFS)比较,差异无统计学意义(P>0.05),而无进展生存率(PFS)、无远处转移生存率(DMFS)比较,差异有统计学意义(P<0.05)。年龄、吸烟史、T分期、N分期和临床分期对OS、PFS和DMFS有显著影响(P<0.05)。恶性肿瘤家族史是PFS的独立良好预后因素(P=0.033),年龄、T分期、N分期是鼻咽癌预后的独立影响因素。患恶性肿瘤亲属人数对LRRFS有影响(P=0.036),但对OS、PFS和DMFS无影响。结论恶性肿瘤家族史是PFS的独立良好预后因素,年龄、T分期和N分期是鼻咽癌的独立预后因素。肿瘤类型和亲属分级对有恶性肿瘤家族史的鼻咽癌患者预后无显著影响。Objective To explore the influence of family history of malignant tumor on the prognosis of patients with nasopharyngeal carcinoma.Methods From February 2010 to October 2016,a total of 1,211 pa-tients with nasopharyngeal carcinoma in the hospital were selected and divided into the group without family history of malignant tumor(group A)and the group with family history of malignant tumor(group B).The family history,baseline characteristics and survival of malignant tumors in the two groups were compared,and the influencing factors of prognostic were analyzed.Results Among 1211 patients,215(17.8%)had a family history of malignant tumors.There were no significant differences in sex,smoking history,drinking history,N stage,chemotherapy mode and radiotherapy technology between the two groups(P>0.05),but there were significant differences in age,T stage and clinical stage(P<0.05).There were no significant differences in overall survival rate(OS)and local regional recurrence-free survival(LRRFS)between the two groups(P>0.05),but there were significant differences in progression free survival(PFS)and distant metastasis free sur-vival(DMFS)between the two groups(P<0.05).It's Age,smoking history,T stage,N stage and clinical stage that had significant effects on OS,PFS and DMFS(P<0.05).Family history of malignant tumor was an independent good prognostic factor for PFS(P=0.033).The Age,T stage and N stage were independent prognostic factors for nasopharyngeal carcinoma.The number of relatives with malignant tumors had an effect on LRRFS(P=0.036),but had no effect on OS,PFS and DMFS.Conclusion Family history of malignant tumor is an independent good prognostic factor for PFS.Age,T stage and N stage are independent prognostic factors for nasopharyngeal carcinoma.Tumor type and relative grade had no significant influence on the prog-nosis of nasopharyngeal carcinoma patients with family history of malignant tumor.

关 键 词：恶性肿瘤家族史 鼻咽癌 临床特征 预后 

分 类 号：R739.62[医药卫生—肿瘤]