β-折叠抗菌肽的研发及应用策略  

Development and Application Strategy of Beta Sheet Antimicrobial Peptides

作　　者：邵长轩 党安凯 战昭含 来振衡 朱永杰 单安山[1] SHAO Changxuan;DANG Ankai;ZHAN Zhaohan;LAI Zhenheng;ZHU Yongjie;SHAN Anshan(Institute of Animal Nutrition,Northeast Agricultural University,Harbin150030,China)

机构地区：[1]东北农业大学动物营养研究所,哈尔滨150030

出　　处：《畜牧兽医学报》2022年第8期2490-2501,共12页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(32030101;31872368);黑龙江省自然科学基金团队项目(TD2019C001);东北农业大学第五层次B类引进人才项目(54916112)。

摘　　要：抗生素的滥用导致全球细菌耐药性问题愈发严重,严重威胁人类、畜禽健康及畜牧业发展,功能多样且不易导致细菌产生耐药性突变的抗菌肽(antimicrobial peptides,AMPs)逐渐发展为抗生素的潜在替代品。β-折叠是抗菌肽一个主要的二级结构分类,该类肽通常由一个或多个二硫键来维系结构的稳定,现已发现许多抗菌肽具有此类结构。相比于目前研究广泛的α-螺旋AMP,它们被认为拥有更强的抗酶解能力和更高的细胞选择性。本篇综述介绍了β-折叠抗菌肽的来源和抗细菌机理,并梳理了一些常见的分子设计方法和应用策略,以期为β-折叠抗菌肽的研发应用提供新思路。The abuse of antibiotics has led to the problem of bacterial resistance more and more serious in the world,which has posed a great threat to the health of human beings and livestock as well as the development of animal husbandry.Antimicrobial peptides(AMPs),which have diverse functions and are not tend to cause bacterial resistance,have gradually developed into potential substitutes of antibiotics.β-sheet structure is a major secondary element constituting the classification of AMPs,which usually maintains the structural stability through one or more disulfide bonds.Compared with the widely studiedα-helical AMP,they are believed to have stronger resistance to enzymolysis and higher cell selectivity.This review briefly introduces the natural sources and antibacterial mechanism ofβ-sheet AMPs,and sorts out some common molecular design methods and application strategies.The content obtained here can provide novel ideas for the research and application ofβ-sheet AMPs.

关 键 词：β-折叠抗菌肽 分子设计 抑菌机理 应用策略 

分 类 号：S859.79[农业科学—临床兽医学] R914.2[农业科学—兽医学]