黄酮化合物脱水闭环反应的研究进展  

Research Advances in the Dehydration and Ring-Closure Reaction for Flavonoids

作　　者：胡水 李厚金[1] 赖瑢[1] 朱可佳[1] 彭敏[1] 李莲云[1] Shui Hu;Houjin Li;Rong Lai;Kejia Zhu;Min Peng;Lianyun Li(School of Chemistry,Sun Yat-Sen University,Guangzhou 510275,China)

机构地区：[1]中山大学化学学院,广州510275

出　　处：《大学化学》2022年第7期85-90,共6页University Chemistry

基　　金：广东省高等教育教学改革项目;中山大学教学改革研究项目。

摘　　要：黄酮具有重要的医用药用价值,其化学合成研究是一大热点。传统化学合成方法通常是由β-丙二酮闭环脱水生成,然而这种方法存在反应时间长、产率低,以及产物难分离等缺点。因此,寻求更加高效、绿色环保的合成方法势在必行。本文主要介绍了近年来国内外以清洁高效的条件通过催化脱水闭环反应制备黄酮化合物的研究进展。Flavonoids play an important role in medicine, and its chemical synthesis is the research hotspot.Flavonoids are usually synthesized by the dehydration and ring closure of β-propanedione. However, the traditional method has several defects, such as long reaction time, low yield and difficulty in separation. Development of more efficient and more environmental friendly synthetic methods is imperative. Herein, we summarize the recent research progresses in the preparation of flavonoids by dehydration and ring-closure reactions under different conditions.

关 键 词：黄酮 β-丙二酮 脱水 闭环反应 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]