支链氨基酸代谢异常在心力衰竭发生发展中作用的研究进展  

Research progress in role of abnormal metabolism of branched-chain amino acid in occurrence and development of heart failure

作　　者：赵菲 牛小伟[2] 刘永铭[3] ZHAO Fei;NIU Xiao-Wei;LIU Yong-Ming(First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Cardiology,First Hospital of Lanzhou University,Lanzhou 730000,China;Department of Geriatric Cardiology,First Hospital of Lanzhou University,Gansu Provincial Clinical Research Center for Geriatric Medicine,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院心血管内科,兰州730000 [3]兰州大学第一医院老年心血管科,甘肃省老年疾病临床医学研究中心,兰州730000

出　　处：《中华老年多器官疾病杂志》2022年第7期544-547,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家自然科学基金(82000277,82060807);甘肃省卫生行业科研计划项目(GSWSKY2019-08);甘肃省科技计划项目(21JR1RA100);中央高校基本科研业务费专项资金资助(lzujbky-2021-kb34);兰州大学第一医院院内基金项目(ldyyyn2019-46)。

摘　　要：心肌能量代谢改变在心力衰竭的发生发展中起着重要作用。近年来研究发现,血浆中支链氨基酸(BCAAs)及其代谢产物水平的增高是心力衰竭的重要特征,并形成恶性反馈环,最终导致心力衰竭进展。因此,促进BCAAs分解代谢、减少代谢产物蓄积及恢复BCAAs代谢平衡,有望成为心力衰竭的新治疗靶点。本文对BCAAs代谢异常与心力衰竭的关系进行综述。The changes of myocardial energy metabolism play an important role in the occurrence and development of heart failure.In recent years,it has been found that the increase of plasma branched-chain amino acid(BCAAs)and its metabolites is an important feature of heart failure,and forms a malignant feedback loop,which will eventually lead to the progression of heart failure.By promoting the catabolism of BCAAs,reducing the accumulation of metabolites and restoring the metabolic balance of BCAAs are expected to become a new target for the treatment of heart failure.This article reviews the association between abnormal metabolism of BCAAs and heart failure.

关 键 词：氨基酸 支链 心力衰竭 代谢重构 

分 类 号：R589.3[医药卫生—内分泌]