Nrf2、TET2蛋白表达与非小细胞肺癌病理特征及预后的关系  

Relationship between Nrf2, TET2 protein expression and pathological features and prognosis of non-small cell lung cancer

作　　者：冯佳[1] 袁傲[1] 黄芳[1] 章建国[1] Feng Jia;Yuan Ao;Huang Fang;Zhang Jianguo(Department of pathology,affiliated hospital of Nantong University,Nantong,Jiangsu,226001,China)

机构地区：[1]南通大学附属医院病理科,江苏南通226001

出　　处：《齐齐哈尔医学院学报》2022年第12期1118-1121,共4页Journal of Qiqihar Medical University

摘　　要：目的 探究细胞核细胞系相关因子2(Nrf2)、十十一易位酶2(TET2)蛋白表达与非小细胞肺癌病理特征及预后的关系。方法 选择2021年1月—2022年1月本院收治的82例非小细胞肺癌患者作为研究对象,按照12个月内治疗情况分为预后良好组(62例)和预后不良组(20例)两组。取早期患者术中的组织标本,晚期活检取的组织,于患者入院24小时内收集并整理所有受试者的临床资料,完成血肌酐(Scr)水平、糖蛋白抗原15-3(CA15-3)及癌胚抗原(CEA)、TET2及Nrf2检测。采用Logistic多因素回归分析非小细胞肺癌发病的影响因素,观察非小细胞肺癌患者的TET2及Nrf2蛋白阳性表达以及分析Nrf2、TET2蛋白表达与非小细胞肺癌病理特征及预后的关系。结果 术后随访12个月,非小细胞肺癌患者预后不良发生20例,发生率为24.39%。预后不良患者CEA、CA15-3、TET2蛋白表达高于预后良好患者,Nrf2蛋白表达低于预后良好患者(P<0.05)。以非小细胞肺癌患者预后为因变量(赋值情况:预后良好患者=1,预后不良患者=0),将CEA水平、CA15-3水平、TET2、Nrf2设为自变量,并对其进行赋值。经多因素Logistic回归分析,CEA水平、CA15-3水平、TET2、Nrf2均是非小细胞肺癌预后不良患者的危险因素(P<0.05)。结论 非小细胞肺癌患者TET2水平高于正常肺组织,Nrf2水平低于正常肺组织,TET2、Nrf2均是非小细胞肺癌预后不良患者的危险因素。Objective To investigate the relationship between the expression of nuclear factor erythroid 2-related factor 2(Nrf2) and ten-eleven translocation 2(TET2) and the pathological characteristics and prognosis of non-small cell lung cancer.Methods 82 patients with non-small cell lung cancer those were ever been treated in our hospital from January 2021 to January 2022 were selected as the research objects, patients were divided into good prognosis group(n=62) and poor prognosis group(n=20) according to treatment within 12 months. Tissue samples were collected during operation from early patients and tissues were collected during advanced biopsies, clinical data of all subjects were collected and sorted out within 24 hours after admission, and concentration of blood creatinine(SCR), glycoprotein antigen 15-3(CA15-3), carcinoembryonic antigen(CEA), TET2 and Nrf2 were detected. Multivariate logistic regression was used to analyze the factors affecting the morbidity of non-small cell lung cancer. The positive expression of TET2 and Nrf2 protein and the relationship between Nrf2 and TET2 protein expression and pathological characteristics and prognosis of non-SCLC patients were observed.Results The patients were followed up for 6 months, 20 patients with non-small cell lung cancer had poor prognosis, and the incidence rate was 24.39%. The expression of CEA, CA15-3 and TET2 protein in patients with poor prognosis were higher than those in patients with good prognosis, and the expression of Nrf2 protein was lower than that in patients with good prognosis(P<0.05). Taking the prognosis of patients with non-small cell lung cancer as the dependent variable(assignment: Patients with good prognosis=1, patients with poor prognosis = 0),levels of CEA,CA15-3,TET2 and Nrf2 were set as independent variables and assign them.Multivariate logistic regression analysis showed that CEA level,CA15-3 level,TET2 and Nrf2 were risk factors for poor prognosis of patients with non-small cell lung cancer( P < 0. 05). Conclusions The level of TET2

关 键 词：非小细胞肺癌 细胞核细胞系相关因子2 十十一易位酶2 病例特征 

分 类 号：R734.2[医药卫生—肿瘤]