调神拍打功联合止颤颗粒对帕金森病患者的影响  

Effect of Tiaoshen Patting Therapy Combined with Zhichan Granule on Patients with Parkinson's Disease

作　　者：蔡丽[1,2] 韩悦 王泰东[1,2] 顾琳奕 朱焜 刘毅[1,2] CAI Li;HAN Yue;WANG Taidong;GU Linyi;ZHU Kun;LIU Yi(Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai 200071,China;Shanghai Municipal Hospital of Traditional Chinese Medicine of Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China;The Shanghai Third Rehabilitation Hospital,Shanghai 200072,China)

机构地区：[1]上海市中医医院,上海200071 [2]上海中医药大学附属市中医医院,上海200071 [3]上海市第三康复医院,上海200072

出　　处：《康复学报》2022年第4期345-351,共7页Rehabilitation Medicine

基　　金：上海市卫生健康委员会中医药科研项目(2018LP029);上海市杏林新星项目[ZY(2018-2020)-RCPY-3009];上海市中医医院第二届中医传承项目(SZY.20201250)。

摘　　要：目的:观察调神拍打功联合止颤颗粒对帕金森病(PD)患者运动症状、非运动症状和生活质量的影响。方法:选择上海市中医医院及其医疗联合体脑病科治疗的PD患者228例,按照随机数字表法分为西药治疗组、中西医治疗组、联合治疗组,每组76例。西药治疗组接受PD健康教育及多巴丝肼片治疗,3次/d,7 d/周,共治疗12周;中西医治疗组在西药治疗组基础上接受止颤颗粒治疗,2次/d,7d/周,共治疗12周;联合治疗组在中西医治疗组基础上接受调神拍打功训练,30 min/次,1次/d,3 d/周,共训练12周。治疗前、治疗8周后、治疗12周后分别采用统一帕金森病评定量表(UPDRS)、UPDRS-Ⅲ评价PD严重程度和运动症状;采用帕金森病非运动症状问卷量表(NMSQuest)评定患者非运动症状;采用39项帕金森病生活质量问卷(PDQ-39)评定患者生活质量;评估3组不良反应的差异。结果:与治疗前比较,中西医治疗组、联合治疗组治疗8周后UPDRS总分、UPDRS-Ⅲ评分均明显降低(P<0.05),3组治疗12周后UPDRS总分、UPDRS-Ⅲ评分均明显降低(P<0.05);中西医治疗组治疗12周后NMSQuest、PDQ-39评分明显降低,联合治疗组治疗8、12周后NMSQuest、PDQ-39评分均明显降低,差异均有统计学意义(P<0.05)。与西药治疗组同一时间点比较,中西医治疗组、联合治疗组治疗8、12周后UPDRS总分、UPDRS-Ⅲ评分均明显降低(P<0.05);中西医治疗组治疗8周NMSQuest评分明显降低,治疗12周后PDQ-39评分明显降低,联合治疗组治疗8、12周后NMSQuest、PDQ-39评分均明显降低,差异具有统计学意义(P<0.05)。与中西医治疗组同一时间点比较,联合治疗组治疗8、12周后UPDRS总分、UPDRS-Ⅲ评分、NMSQuest评分、PDQ-39评分均明显降低,差异均有统计学意义(P<0.05)。3组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:调神拍打功联合止颤颗粒可改善PD患者运动症状、非运动症状和生活质量,安全性Objective:To observe the clinical effect of Tiaoshen patting therapy combine with Zhichan granule on tremor,stiffness and postural instability on patients with Parkinson's disease.Methods:A total of 228 patients with Parkinson's disease who were treated in the Shanghai Municipal Hospital of Traditional Chinese Medicine and it's medical consortium,which were randomly divided into Western medicine treatment group,traditional Chinese and Western medicine treatment group and combined treatment group,with 76 cases in each group.The Western medicine treatment group received health education about PD and Dobasazide tablets,three times a day,seven days a week,continuous treatment for 12 weeks;the traditional Chinese and Western medicine treatment group received Zhichan granule on the basis of the Western medicine treatment group,two times a day,seven days a week,continuous treatment for 12 weeks;the combined treatment group received Tiaoshen patting therapy on the basis of the traditional Chinese and Western medicine treatment group,30 minutes a time,one time a day,three days a week,continuous treatment for 12 weeks.Before treatment,after treatment for eight weeks and after treatment for 12 weeks,Unified Parkinson Disease Rating Scale(UPDRS)and UPDRS-Ⅲwere used to evaluate PD severity and motor symptoms;Parkinson's disease non-motor symptoms questionnaire(NMS Quest)was used to evaluate the non motor symptoms of patients;39 item Parkinson's disease quality of life questionnaire(PDQ-39)was used to evaluate the quality of life of patients;the differences of adverse reactions in the three groups were evaluated.Results:Compared with before treatment,the total score of UPDRS and UPDRS-Ⅲin the traditional Chinese and Western medicine treatment group and the combined treatment group after treatment for eight weeks decreased significantly(P<0.05),and the total score of UPDRS and UPDRS-Ⅲin the three groups after treatment for 12 weeks decreased significantly(P<0.05);the scores of NMS Quest and PDQ-39 in the traditional Chine

关 键 词：帕金森病 调神拍打功 止颤颗粒 运动障碍 非运动症状 生活质量 

分 类 号：R742.5[医药卫生—神经病学与精神病学]