信号素7A在免疫炎症及神经系统疾病中的研究进展  

Research progress of semaphorin 7A in immune inflammation and nervous system diseases

作　　者：曹湘玉 汤永红 袁梅 CAO Xiang-yu;TANG Yong-hong;YUAN Mei(Department of Neurology,the Second Affiliated Hospital of Hengyang Medical School,University of South China,Hengyang 421001,China;Department of Diagnostics,School of Medicine,Hunan University of Medicine,Huaihua 418000,China)

机构地区：[1]南华大学衡阳医学院附属第二医院神经内科,衡阳421001 [2]湖南医药学院医学院诊断学教研室,怀化418000

出　　处：《现代免疫学》2022年第4期340-343,共4页Current Immunology

基　　金：湖南省卫计委重大专项课题(A2017019);湖南省中医药科研计划项目(2021219);湖南省教育厅科学研究项目(21C1376);湖南省大学生创新创业训练计划项目(2021-4302)。

摘　　要：信号素(semaphorin,Sema)家族是一组结构高度保守、表达非常广泛、功能多样化的蛋白家族,由20多个家族成员共同组成,分为8种类型,参与多种疾病的病理生理过程。Sema7A是迄今为止Sema家族中唯一一个与糖基化磷脂酰肌醇(glycosylphosphatidylinositol,GPI)相偶联的膜相关糖蛋白。Sema7A主要通过与受体神经丛蛋白C1和整合素α1β1结合而发挥作用。该文就Sema7A的结构、功能及其在免疫炎症、神经系统疾病中的研究现状进行综述,旨在为临床治疗提供潜在的靶点。The semaphorins(Sema)are a family of proteins with highly evolutionary conserved structure,broad expression patterns and diverse functions.Sema family includes more than 20 members that are categorized into 8 classes and these proteins are involved in the pathophysiological process of a variety of diseases.Up to now,Sema7 A is the only membrane-associated glycoprotein in the Sema family that is coupled to glycosylphosphatidylinositol(GPI).Sema7 A works mainly by binding to the receptor plexin C1 and integrinα1β1.This review summarizes the structure and function of Sema7 A and discusses related research progresses in immune inflammation and nervous system diseases,aiming to provide potential targets for clinical treatment.

关 键 词：信号素7A 免疫炎症 神经系统疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]