1990—2019年中国人群非酒精性脂肪肝疾病负担分析  

Disease burden related to non-alcoholic fatty liver disease from 1990 to 2019 in China

作　　者：胡漂[1] 孔东明 朱仲鑫[3] HU Piao;KONG Dong-ming;ZHU Zhong-xin(Department of Infectious Diseases,the First People’s Hospital of Xiaoshan District,Hangzhou Zhejiang 311200 China;不详)

机构地区：[1]杭州市萧山区第一人民医院感染科,浙江杭州311200 [2]杭州市萧山区义桥镇社区卫生服务中心,浙江杭州311200 [3]杭州市萧山区第一人民医院临床研究中心,浙江杭州311200

出　　处：《中国预防医学杂志》2022年第4期260-264,共5页Chinese Preventive Medicine

基　　金：浙江省医药卫生科技计划项目(2021429790);杭州市医药卫生科技计划重点项目(ZD20210013)。

摘　　要：目的通过分析我国1990—2019年非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)疾病负担数据,为公共卫生策略的制定提供依据。方法本研究采用全球疾病负担研究2019数据对我国1990—2019年NAFLD的疾病负担及其变化情况进行描述和分析,具体指标包括发病率、患病率、死亡率和伤残调整寿命年(disability-adjusted life years,DALYs)。联结点回归模型用于确定NAFLD疾病负担变化趋势,并且分析不同年龄组人群的疾病负担。结果自1990年以来,NAFLD发病率在男女中均呈先上升(1990—2000年)后明显下降(2000—2005年)再上升趋势。患病率总体呈明显上升趋势,女性在2017—2019年呈明显下降趋势。死亡率和DALYs的指标1999—2010年在男女中均呈明显下降趋势,而在2011年后,趋势为明显上升。2019年男性85~<90岁年龄组负担最重,女性80~<85岁年龄组负担最重。吸烟和高空腹血糖引起的NAFLD的疾病负担在近几年也明显上升。结论中国人群NAFLD疾病负担在近几年明显上升,且不同年龄段存在明显差异。NAFLD的预防和临床管理应纳入国家卫生政策。Objective To describe the disease burden of non-alcoholic fatty liver disease(NAFLD)during1990 and 2019 in China,and to provide scientific evidence for the formulation of public health policies.Methods Data in the Global Burden of Disease Study 2019 was used to describe and analyze the disease burden of NAFLD and its changes in China from 1990 to 2019 using indicators as morbidity,prevalence,mortality and disability-adjusted life years(DALYs).The Joinpoint regression model was used to determine the overall trend of disease burden of NAFLD as well as the burden of disease in different age groups.Results The incidence of NAFLD in both men and women increased from 1990 to 2000,then largely decreased from 2000 to 2005,increased again after 2005.The overall incidence of NAFLD was on the rise with a downward trend in women during 2017 and 2019.There were significant downward trends in mortality and DALYs from 1999 to 2010,while after 2011,both mortality and DALYs showed upward trends.In 2019,the heaviest disease burden of NAFLD was found in men of 85-<90 years old and in women of 80-<85 years old.The burden of NAFLD caused by smoking and high fasting plasma glucose also increased significantly in recent years.Conclusions The disease burden of NAFLD in China has increased substantially in recent years and varies significantly in different age groups.It is suggested that the prevention and clinical management of NAFLD should be included in the national health policy.

关 键 词：非酒精性脂肪肝 疾病负担 变化趋势 

分 类 号：R575.5[医药卫生—消化系统]