健脾益肾解毒方联合化疗对中晚期胃癌患者免疫功能及肾小管间质损害的影响  

Effects of Jianpi Yishen Jiedu recipe combined with chemotherapy on immune function and renal tubulointerstitial damage in patients with advanced gastric cancer

作　　者：任梅梅[1] 高欣 REN Meimei;GAO Xin(the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)

机构地区：[1]陕西中医药大学第二附属医院,陕西咸阳712000

出　　处：《临床医学研究与实践》2022年第25期121-124,共4页Clinical Research and Practice

摘　　要：目的探讨健脾益肾解毒方联合化疗对中晚期胃癌患者免疫功能及肾小管间质损害的影响。方法选取2019年1月至2021年1月收治的80例中晚期胃癌患者作为研究对象,按照红绿双色球法将其分为对照组(40例,化疗)和研究组(40例,健脾益肾解毒方联合化疗)。比较两组患者的免疫功能、炎症反应指标、内皮素(ET)、一氧化氮(NO)与血清相关指标水平、肾小管间质损害发生率及血管内皮因子水平。结果治疗4个疗程后,研究组的白细胞分化抗原3阳性(CD3^(+))、白细胞分化抗原4阳性(CD4^(+))、白细胞分化抗原4阳性/白细胞分化抗原8阳性(CD4^(+)/CD8^(+))、自然杀伤细胞(NK细胞)高于对照组,白细胞分化抗原8阳性(CD8^(+))低于对照组(P<0.05)。治疗4个疗程后,研究组的白细胞介素-6(IL-6)、C反应蛋白(CRP)、ET、NO水平低于对照组(P<0.05)。治疗4个疗程后,研究组的基质金属蛋白酶9(MMP-9)、基质金属蛋白酶2(MMP-2)水平均低于对照组(P<0.05)。研究组的肾小管间质损害发生率低于对照组(P<0.05)。治疗4个疗程后,研究组的血管内皮生长因子-D(VEGF-D)水平高于对照组,血管内皮细胞生长因子-A(VEGF-A)、血管内皮生长因子受体-1(VEGFR-1)水平低于对照组(P<0.05)。结论健脾益肾解毒方联合化疗治疗中晚期胃癌的效果显著,可改善患者的免疫功能指标及炎症因子、血管内皮因子水平,减少肾小管间质损害的发生,值得临床进一步推广应用。Objective To explore the effects of Jianpi Yishen Jiedu recipe combined with chemotherapy on immune function and renal tubulointerstitial damage in patients with advanced gastric cancer.Methods A total of 80 patients with advanced gastric cancer treated from January 2019 to January 2021 were selected as the research objects,and the patients were divided into control group(40 cases,chemotherapy)and study group(40 cases,Jianpi Yishen Jiedu recipe combined with chemotherapy)according to the red-green double-color ball method.The immune function,inflammatory reaction indicators,endothelin(ET),nitric oxide(NO)and serum related indicators levels,the incidence of renal tubulointerstitial damage and the levels of vascular endothelial factors were compared between the two groups.Results After 4 courses of treatment,the cluster of differentiation 3 positive(CD3^(+)),cluster of differentiation 4 positive(CD4^(+)),cluster of differentiation 4 positive/cluster of differentiation 8 positive(CD4^(+)/CD8^(+)),natural killer cells(NK cells)in the study group were higher than those in the control group,and cluster of differentiation 8 positive(CD8^(+))was lower than that in the control group(P<0.05).After 4 courses of treatment,the levels of interleukin-6(IL-6),C-reactive protein(CRP),ET,NO in the study group were lower than those in the control group(P<0.05).After 4 courses of treatment,the levels of matrix metalloproteinases-9(MMP-9)and matrix metalloproteinases-2(MMP-2)in the study group were lower than those in the control group(P<0.05).The incidence of renal tubulointerstitial damage in the study group was lower than that in the control group(P<0.05).After 4 courses of treatment,the level of vascular endothelial growth factor-D(VEGF-D)in the study group was higher than that in the control group,and the levels of vascular endothelial growth factor-A(VEGF-A)and vascular endothelial growth factor receptor-1(VEGFR-1)were lower than those in the control group(P<0.05).Conclusion Jianpi Yishen Jiedu recipe combined with chemotherapy

关 键 词：中晚期胃癌 健脾益肾解毒方 化疗 免疫功能 

分 类 号：R735.2[医药卫生—肿瘤]