奥扎格雷钠联合依达拉奉治疗基底节区脑梗死的疗效观察  

Efficacy observation of sodium ozagrel combined with edaravone in the treatment of cerebral infarction in basal ganglia region

作　　者：孙闯 SUN Chuang(Shenyang Second Hospital of Chinese Medicine,Shenyang 110101,China)

机构地区：[1]沈阳市第二中医医院,110101

出　　处：《中国实用医药》2022年第17期95-97,共3页China Practical Medicine

摘　　要：目的 观察奥扎格雷钠联合依达拉奉治疗基底节区脑梗死的临床效果。方法 90例基底节区脑梗死患者,按照随机数字表法分为A组、B组及C组,各30例。A组给予奥扎格雷钠进行治疗,B组给予阿司匹林联合依达拉奉进行治疗, C组给予奥扎格雷钠联合依达拉奉进行治疗。比较两组临床疗效及不同时间美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)。结果 治疗14 d后,C组NIHSS评分(10.42±1.37)分低于A组的(11.81±1.52)分和B组的(11.98±.45)分,差异有统计学意义(P<0.05), A组NIHSS评分与B组比较差异无统计学意义(P>0.05);治疗14 d后,三组Barthel指数比较差异无统计学意义(P>0.05);出院90 d后, C组NIHSS评分(6.05±0.64)分低于A组的(8.97±1.09)分和B组的(8.35±1.37)分, Barthel指数(86.49±13.49)分高于A组的(76.18±12.37)分和B组的(69.65±11.07)分,差异有统计学意义(P<0.05);出院出院90 d后, A组NIHSS评分与B组比较差异无统计学意义(P>0.05), A组Barthel指数(76.18±12.37)分高于B组的(69.65±11.07)分,差异有统计学意义(P<0.05)。C组总有效率86.67%明显高于A组的56.67%和B组的63.33%,差异有统计学意义(P<0.05);A组总有效率与B组比较差异无统计学意义(P>0.05)。结论 对基底节区脑梗死患者应用奥扎格雷钠联合依达拉奉治疗,在合理应用抗血小板药物的同时早期使用神经保护剂,并重视院后抗血小板药物的合理使用,提高依从性,及时调整药物,能有效提高患者生活质量,改善预后。Objective To observe the clinical effect of sodium ozagrel combined with edaravone in the treatment of cerebral infarction in basal ganglia region.Methods A total of 90 patients with cerebral infarction in basal ganglia region were randomly divided into group A,group B and group C,with 30 cases in each group.Group A was treated with sodium ozagrel,group B was treated with aspirin combined with edaravone,and group C was treated with sodium ozagrel combined with edaravone.The clinical efficacy,National Institutes of Health stroke scale(NIHSS)score and Barthel index(BI)at different time points were compared between the two groups.Results After 14 d of treatment,the NIHSS score(10.42±1.37)points of group C was lower than(11.81±1.52)points of group A and(11.98±.45)points of group B,and the differences were statistically significant(P<0.05).There was no statistically significant difference in NIHSS score between group A and group B(P>0.05).After 14 d of treatment,there was no statistically significant difference in Barthel index among the three groups(P>0.05).At 90 d after discharge,the NIHSS score(6.05±0.64)points of group C was lower than(8.97±1.09)points of group A and(8.35±1.37)points of group B;the Barthel index(86.49±13.49)points of group C was higher than(76.18±12.37)points of group A and(69.65±11.07)points of group B;all the difference was statistically significant(P<0.05).At 90 d after discharge,there was no statistically significant difference in the NIHSS score between group A and group B(P>0.05).The Barthel index(76.18±12.37)points of group A was higher than(69.65±11.07)points of group B,and the difference was statistically significant(P<0.05).The total effective rate of group C(86.67%)was significantly higher than that of group A(56.67%)and group B(63.33%),and the difference was statistically significant(P<0.05).There was no statistically significant difference in the total effective rate between group A and group B(P>0.05).Conclusion For patients with cerebral infarction in the basal ganglia re

关 键 词：奥扎格雷钠 依达拉奉 基底节区脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]