药物性肝损伤的临床特征分析  

Analysis of clinical features of drug-induced liver injury

作　　者：宋磊 SONG Lei(Dalian Fifth People's Hospital,Dalian 116021,China)

机构地区：[1]大连市第五人民医院,116021

出　　处：《中国实用医药》2022年第17期170-172,共3页China Practical Medicine

摘　　要：目的 分析药物性肝损伤患者的临床特征。方法 328例药物性肝损伤患者作为研究对象,对其临床资料进行收集整理。回顾性分析药物性肝损伤患者的性别、损伤类型、药物种类及临床症状。结果 328例药物性肝损伤患者男性患者占比为53.66%(176/328),女性患者占比为46.34%(152/328),男性患者占比高于女性患者。328例药物性肝损伤患者中262例为肝细胞损伤,占比为79.88%;49例为胆汁淤积型损伤,占比为14.94%;17例为混合型损伤,占比为5.18%。中西药联合用药导致药物性肝损伤166例,占比为50.61%;使用中成药和中草药导致药物性肝损伤107例,占比为32.62%;使用抗炎药、激素类药物、抗肿瘤药物、保健品等导致药物性肝损伤55例,占比为16.77%。328例药物性肝损伤患者中临床症状包括食欲不振、皮疹、瘙痒、腹痛、黄疸和无症状等,具体分布为食欲不振89例、占比为27.13%;黄疸212例、占比为64.63%;皮疹23例、占比为7.01%;瘙痒29例、占比为8.84%;腹痛77例、占比为23.48%;无症状11例,占比为3.35%。结论 药物性肝损伤患者中大部分为肝细胞损伤,由中西医联合或使用中成药和中草药引起药物性肝损伤的可能性较大,此外抗炎药、激素类药物、抗肿瘤药物等也可引起药物性肝损伤,因此临床应当加强对药物性肝损伤的关注,积极治疗和预防,减少相关危害。Objective To analyze the clinical features of drug-induced liver injury.Methods 328 patients with drug-induced liver injury were selected as the research subjects,and their clinical data were collected.The gender,injury type,drug types and clinical symptoms in patients with drug-induced liver injury were retrospectively analyzed.Results Among the 328 patients with drug-induced liver injury,the proportion of males was 53.66%(176/328),and the proportion of females was 46.34%(152/328);the proportion of males was higher than that of females.Among the 328 patients with drug-induced liver injury,262 cases had hepatocyte injury,accounting for 79.88%;49 cases had cholestatic injury,accounting for 14.94%;and 17 cases had mixed injury,accounting for 5.18%.166 cases of drug-induced liver injury were caused by the combination of traditional Chinese and Western medicines,accounting for 50.61%;107 cases of drug-induced liver injury were caused by the use of Chinese patent medicines and Chinese herbal medicine,accounting for 32.62%;the remaining 55 cases of drug-induced liver injury were caused by anti-inflammatory drugs,including hormone drugs,antitumor drugs,and health products,accounting for 16.77%.Among the 328 patients with drug-induced liver injury,the clinical symptoms included loss of appetite,rash,itching,abdominal pain,jaundice and asymptomatic,etc.The specific distribution was loss of appetite in 89 cases,accounting for 27.13%;jaundice in 212 cases,accounting for 64.63%;rash in 23 cases,accounting for 7.01%;itching in 29 cases,accounting for 8.84%;abdominal pain in 77 cases,accounting for 23.48%;11 patients were asymptomatic,accounting for 3.35%.Conclusion Among patients with drug-induced liver injury,most of the patients are liver cell injury,and the possibility of druginduced liver injury caused by the combination of Chinese and Western medicine or the use of Chinese patent medicine and Chinese herbal medicine is greater.In addition,anti-inflammatory drugs,hormone drugs and antitumor drugs can also cause drug-induc

关 键 词：药物性肝损伤 中西药联合 中草药 中成药 

分 类 号：R575[医药卫生—消化系统]