多肽探针在肿瘤成像中的研究进展  

Research progress of peptide probe in tumor imaging

作　　者：郭玲(综述) 苏亚娟(审校)[1] GUO Ling;SU Yajuan(Department of Clinical Laboratory,Harbin Medical University Cancer Hospital,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院检验科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2022年第4期360-363,共4页Practical Oncology Journal

基　　金：海燕科研基金(编号:JJZD2022-01)。

摘　　要：肿瘤的精准成像在识别肿瘤位置和分期以及确定合适的治疗方法方面发挥着重要作用。多肽是在成像方面具有前途的工具,已证明相应的受体在肿瘤细胞中过表达,通过与受体特异性结合导致显像剂在肿瘤细胞内成像。此外,由于多肽具有分子量小、免疫原性低、亲和力和特异性高等众多优点使其在肿瘤诊断和治疗中受到越来越多的关注,一些基于多肽的成像探针和治疗剂已成功进入临床试验。本文就多肽探针在肿瘤成像中的研究进展进行综述。Accurate imaging of tumors plays an important role in identifying tumor location and staging,and determining the appropriate treatment methods.Peptides are promising tools in imaging,and the corresponding receptors have been shown to be overexpressed in tumor cells,leading to imaging agents within tumor cells by specifically binding to the receptors.In addition,peptides have attracted more and more attention in tumor diagnosis and treatment due to their small molecular weight,low immunogenicity,high affinity and specificity,and some peptide-based imaging probes and therapeutic agents have successfully entered clinical trials.This article reviews the research progress of peptide probes in tumor imaging.

关 键 词：多肽探针 肿瘤 成像诊断 

分 类 号：R730[医药卫生—肿瘤]