化学发光免疫法测定甲胎蛋白及糖类抗原19-9在原发性肝癌诊断中的应用价值  

Application value of chemiluminescence immunoassay for determination of AFP and carbohydrate antigen19-9 in primary liver cancer

作　　者：李青梅 LI Qingmei(Department of Laboratory,Guixi People's Hospital,Guixi,Jiangxi,335400,China)

机构地区：[1]贵溪市人民医院检验科,江西贵溪335400

出　　处：《当代医学》2022年第16期36-39,共4页Contemporary Medicine

摘　　要：目的探讨化学发光免疫法测定甲胎蛋白(AFP)、糖类抗原19-9(CA19-9)在原发性肝癌诊断中的应用价值。方法选取2017年8月至2020年8月本院收治的80例肝脏疾病患者作为研究对象,所有患者行磁共振检查后,根据磁共振检查结果分为良性肝病组(n=19)和原发性肝癌组(n=61)。统计核磁共振检查结果,比较两组临床资料、AFP、CA19-9水平及阳性率,分析血清AFP、CA19-9单独检测及联合检测诊断原发性肝癌的价值。结果80例患者中,良性肝病61例,其中单纯性肝囊肿31例,肝血管瘤18例,局灶性结节增生7例,炎症性病变5例;原发性肝癌19例,其中结节型9例,巨块型6例,弥漫型4例。原发性肝癌组血清AFP、CA19-9水平均高于良性肝病组,差异有统计学意义(P<0.05)。原发性肝癌组血清AFP、CA19-9阳性率均高于良性肝病组,差异有统计学意义(P<0.05)。ROC曲线结果显示,血清AFP、CA19-9水平单独检测及联合检测原发性肝癌的AUC分别为0.757、0.843、0.869,诊断价值均较好,且以联合检测的诊断价值最高。结论采用化学发光免疫法测定血清AFP、CA19-9水平在诊断原发性肝癌中具有重要价值,联合检测能提高原发性肝癌诊断的准确度,可提高患者生存率及生存质量,值得临床推广应用。Objective To investigate the application value of chemiluminescence immunoassay for determination of alpha-fetoprotein(AFP)and carbohydrate antigen 19-9(CA19-9)in the diagnosis of primary liver cancer.Methods 80 patients with liver disease admitted to our hospital fromAugust 2017 to August 2020 were selected as the research subjects,after magnetic resonance examination,all patients were divided into benign liver disease group(n=19)and primary liver cancer group(n=61)according to the results of magnetic resonance examination.The magnetic resonance imaging results were counted,the clinical data,AFP,CA19-9 levels and positive rates were compared between the two groups,and the serum AFP,CA19-9 single detection and combined detection in the diagnosis of primary liver cancer were analyzed.Results Among the 80 patients,61 cases had benign liver disease,including 31 cases simple hepatic cysts,18 cases hepatic hemangioma,7 cases focal nodular hyperplasia,and 5 cases inflammatory lesions;19 cases had primary liver cancer,including 9 casese nodular type,6 cases of massive type,4 cases of diffuse type.The serum levels of AFP and CA19-9 in the primary liver cancer group were higher than those in the benign liver disease group,and the difference was statistically significant(P<0.05).The positive rates of serum AFP and CA19-9 in the primary liver cancer group were higher than those in the benign liver disease group,and the difference was statistically significant(P<0.05).The results of ROC curve showed that the AUC of serumAFP and CA19-9 levels for single detection and combined detection of primary liver cancer were 0.757,0.843 and 0.869,respectively,with good diagnostic value,and the combined detection had the best diagnostic value.Conclusion The determination of serumAFP and CA19-9 levels by chemiluminescence immunoassay is of great value in the diagnosis of primary liver cancer.combined detection can improve the accuracy of the diagnosis of primary liver cancer,and has a positive effect on clinical improvement of the surviva

关 键 词：原发性肝癌 化学发光免疫法 甲胎蛋白 糖类抗原19-9 

分 类 号：R735.7[医药卫生—肿瘤]