β-苯乙醇连续流合成工艺研究  

Continuous Flow Synthesis of β-Phenylethanol

作　　者：申屠有德 金毅强 姚跃良 毛海舫 SHENTU Youde;JIN Yiqiang;YAO Yueliang;MAO Haifang(Shandong Apeloa Hanxing Pharmaceutical Co.,Ltd.,Changyi 261312,Shandong,China;School of Chemical and Environmental Engineering,Shanghai Institute of Technology,Shanghai 201418,China)

机构地区：[1]山东普洛汉兴医药有限公司,山东昌邑261312 [2]上海应用技术大学化学与环境工程学院,上海201418

出　　处：《香料香精化妆品》2022年第4期79-81,99,共4页Flavour Fragrance Cosmetics

摘　　要：以氯苯为原料进行格氏反应,格氏反应液和环氧乙烷经过T型微混合器迅速混合,混合液再流经由微反应器和管道反应器组成的组合反应器完成反应生成β-苯乙醇。考察了反应温度、停留时间等对反应的影响。结果表明:微反应器温度20℃,管道反应器温度60℃,总停留时间1 h,反应物料进料总体积流量4.35 mL/min时,β-苯乙醇的反应收率达到89.5%。Chlorobenzene was used as the raw material,Grignard reagent phenyl-magnesium chloride was prepared from chlorobenzene.Then the Grignard reagent and ethylene oxide were mixed rapidly in the T-shape microchannel reactor to formβ-phenylethanol.Effects of the reaction temperature and the residence time were investigated.Results showed that under the optimum conditions of the micro reactor reaction temperature of 20℃and the tubular reactor reaction temperature of 60℃,the yield ofβ-phenylethanol was 89.5%with the total residence time of 1 h and the total flow rate of 4.35 mL/min.

关 键 词：格氏试剂 缩合反应 微反应器 Β-苯乙醇 

分 类 号：TQ243.4[化学工程—有机化工]