白介素-1受体相关激酶的免疫调控及其在炎症性肠病中的研究进展  

Advances in immune regulation of interleukin-1 receptor-associated kinases and its research on inflammatory bowel disease

作　　者：段正兰 冯泽宇 王包晟 刘慧泽 陈玉根(指导)[1] DUAN Zhenglan;FENG Zeyu;WANG Baosheng;LIU Huize;CHEN Yugen(The First Clinical Medical College Affiliated of Nanjing University of Chinese Medicine,Nanjing 210000,China)

机构地区：[1]南京中医药大学附属第一临床医学院,南京210000

出　　处：《中国免疫学杂志》2022年第12期1528-1534,共7页Chinese Journal of Immunology

基　　金：国家自然科学基金面上项目(81873309);2020年江苏省研究生科研创新计划(KYCX20-1532)资助。

摘　　要：白介素-1受体相关激酶家族(IRAKs)是一类丝氨酸-苏氨酸激酶,介导来自TLRs和白介素-1受体(IL-1R)的信号激活。IRAKs由4名成员组成:IRAK1、IRAK2、IRAKM、IRAK4,与先天免疫、适应性免疫和炎症的正向或负向调节密切相关。越来越多证据表明,IRAKs在炎症性肠病(IBD)发生发展中起重要免疫调节作用。本文就IRAKs的结构、功能、转录和调控及其在IBD中的作用进行综述,以期寻找新的IBD诊治靶点。Interleukin-1 receptor-associated kinases(IRAKs)are serine-threonine kinases involved in activation of TLRs and interleukin-1 receptor(IL-1R)signaling.IRAKs are consisting of 4 members:IRAK1,IRAK2,IRAKM and IRAK4,which are closely related to innate immunity,adaptive immunity and positive or negative regulation of inflammation.Evidence exists that IRAKs play key roles in immune regulation of development and progression of inflammatory bowel disease(IBD).This paper reviews structure,function,transcription and regulation of IRAKs,as well as its role in IBD,and in order to find a new target for diagnosis and treatment of IBD.

关 键 词：白介素1受体相关激酶 炎症性肠病 免疫调节 

分 类 号：R574.1[医药卫生—消化系统]