托拉塞米和呋塞米治疗脑出血后急性脑水肿的效果评价  

Effect evaluation of torasemide and furosemide in the treatment of acute cerebral edema after intracerebral hemorrhage

作　　者：王开 WANG Kai(Department of Neurology,Fukuang General Hospital,Liaoning Health Industry Group,Fushun 113008,China)

机构地区：[1]辽宁省健康产业集团抚矿总医院神经内科三病房,113008

出　　处：《中国现代药物应用》2022年第14期1-4,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 观察托拉塞米和呋塞米治疗脑出血后急性脑水肿的临床效果。方法 82例脑出血后急性脑水肿患者,随机分为观察组与对照组,各41例。对照组采用呋塞米治疗,观察组采用托拉塞米治疗。对比两组治疗前后颅内压水平、尿量、并发症发生情况、日常生活能力及神经缺损程度评分。结果 治疗3、5、7、14 d,观察组颅内压水平分别为(16.21±0.53)、(15.32±0.52)、(14.83±0.42)、(13.17±0.53)mm Hg(1 mm Hg=0.133 kPa),均低于对照组的(17.94±1.34)、(16.94±0.73)、(15.97±0.61)、(14.85±0.38)mm Hg,差异均有统计学意义(P<0.05)。治疗3、5、7、14 d,观察组尿量分别为(3856.36±572.12)、(3857.69±562.18)、(3797.62±433.71)、(3893.81±412.74)ml,均多于对照组的(3519.67±570.83)、(3619.51±491.62)、(3610.15±402.62)、(3704.51±419.62)ml,差异均有统计学意义(P<0.05)。治疗后,观察组日常生活活动能力(ADL)评分(67.94±7.41)分高于对照组的(58.52±7.93)分,美国国立卫生研究院卒中量表(NIHSS)评分(7.52±1.39)分低于对照组的(11.87±1.84)分,差异均有统计学意义(P<0.05)。观察组并发症发生率4.88%低于对照组的21.95%,差异有统计学意义(P<0.05)。结论 托拉塞米治疗脑出血后急性脑水肿患者,能降低颅内压,增加尿量,促进其日常生活能力的提升,有利于神经功能恢复,且并发症少,整体效果优于呋塞米,值得推广应用。Objective To observe the clinical effect of torasemide and furosemide in the treatment of acute cerebral edema after intracerebral hemorrhage.Methods A toal of 82 patients with acute cerebral edema after cerebral hemorrhage were randomly divided into observation group and control group,with 41 cases in each group.The control group was treated with furosemide,and the observation group was treated with torasemide.The intracranial pressure level,urine output,complication rate,activities of daily living and neurological deficit score before and after treatment were compared between the two groups.Results After 3,5,7,and 14 d of treatment,the intracranial pressure levels in the observation group were(16.21±0.53),(15.32±0.52),(14.83±0.42),and(13.17±0.53)mm Hg(1 mm Hg=0.133 kPa),which were lower than(17.94±1.34),(16.94±0.73),(15.97±0.61),and(14.85±0.38)mm Hg in the control group,and the differences were statistically significant(P<0.05).After 3,5,7,and 14 d of treatment,the urine output of the observation group were(3856.36±572.12),(3857.69±562.18),(3797.62±433.71),and(3893.81±412.74)ml,which were all higher than(3519.67±570.83),(3619.51±491.62),(3610.15±402.62),and(3704.51±419.62)ml of the control group,and the differences were statistically significant(P<0.05).After treatment,the activities of daily living(ADL)score(67.94±7.41)points of the observation group was higher than(58.52±7.93)points of the control group,and the National Institutes of Health stroke scale(NIHSS)score(7.52±1.39)points was lower than(11.87±1.84)points of the control group.All the differences were statistically significant(P<0.05).The complication rate 4.88%in the observation group was lower than 21.95%in the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment of patients with acute cerebral edema after cerebral hemorrhage with torasemide can reduce intracranial pressure,increase urine output,promote their activities of daily living,and facilitate the recovery of neurological function

关 键 词：托拉塞米 呋塞米 脑出血 急性脑水肿 效果 

分 类 号：R743.34[医药卫生—神经病学与精神病学]