盐酸曲马多缓释片治疗肝癌疼痛的效果评价  

Evaluation of the effect of tramadol hydrochloride sustained-release tablets in the treatment of liver cancer pain

作　　者：李敏 LI Min(Department of Pharmacy,Liaoning Health Industry Group Fukuang General Hospital,Fushun 113008,China)

机构地区：[1]辽宁健康产业集团抚矿总医院药剂科,113008

出　　处：《中国现代药物应用》2022年第14期134-136,共3页Chinese Journal of Modern Drug Application

摘　　要：目的评价盐酸曲马多缓释片治疗肝癌疼痛的临床效果。方法86肝癌疼痛患者,随机分为对照组和观察组,各43例。对照组患者采取羟考酮缓释片进行镇痛治疗,观察组患者采取盐酸曲马多缓释片进行镇痛治疗。比较两组患者镇痛效果、不良反应发生情况及生活质量、不良情绪评分。结果两组镇痛总有效率比较,差异无统计学意义(P>0.05)。观察组不良反应发生率20.93%低于对照组的46.51%,差异有统计学意义(P<0.05)。观察组患者生活质量量表(QOL)评分(49.50±3.50)分高于对照组的(37.50±4.30)分,抑郁自评量表(SDS)评分(22.50±2.50)分、焦虑自评量表(SAS)评分(23.20±2.30)分均低于对照组(32.30±3.30)、(32.20±3.05)分,差异有统计学意义(P<0.05)。结论肝癌疼痛患者应用盐酸曲马多缓释片进行镇痛的效果与羟考酮缓释片相比差异不大,但其安全性更高,可有效改善患者生活质量与不良情绪。Objective To evaluate the clinical effect of tramadol hydrochloride sustained-release tablets in the treatment of liver cancer pain.Methods A total of 86 patients with liver cancer pain were randomly divided into control group and observation group,with 43 cases in each group.Patients in the control group received oxycodone hydrochloride prolonged-release tablets for analgesia,and patients in the observation group received tramadol hydrochloride sustained-release tablets for analgesia.The analgesic effects,occurrence of adverse reactions,quality of life and negative emotion scores were compared between the two groups.Results There was no statistically significant difference in the total effective rate of analgesia between the two groups(P>0.05).The incidence of adverse reactions 20.93%in the observation group was lower than 46.51%in the control group,and the difference was statistically significant(P<0.05).The quality of life scale(QOL)score(49.50±3.50)points in the observation group was higher than(37.50±4.30)points of the control group,and the self-rating depression scale(SDS)score(22.50±2.50)points,the self-rating anxiety scale(SAS)score(23.20±2.30)points were lower than(32.30±3.30)and(32.20±3.05)points of the control group.All the differences were statistically significant(P<0.05).Conclusion The analgesic effect of tramadol hydrochloride extended-release tablets for analgesia in patients with liver cancer pain is not significantly different from that of oxycodone hydrochloride prolonged-release tablets,but it is safer and can effectively improve patients'quality of life and negative emotion.

关 键 词：盐酸曲马多缓释片 羟考酮缓释片 肝癌疼痛 生活质量 不良反应 镇痛效果 

分 类 号：R735.7[医药卫生—肿瘤]