药物治疗精神分裂症的经济学评价模型研究  

The economic evaluation model of drug therapy for schizophrenia

作　　者：闫蓓蓓 席晓宇[1] YAN Bei-bei;XI Xiao-yu(The Research Center of National Drug Policy&Ecosystem,China Pharmaceutical University,Jiangsu Nanjing 211198,China)

机构地区：[1]中国药科大学国家药物政策与医药产业经济研究中心,江苏南京211198

出　　处：《中国医院药学杂志》2022年第14期1458-1462,共5页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研究适用于药物治疗精神分裂症的不同药物经济学模型,为该疾病领域的药物经济学评价合理选择模型提供参考。方法:使用文献研究法,结合研究特征和模型的结构分析经济学评价模型的特点和适用性。结果:最终纳入62篇研究,其中22篇(50.00%)采用马尔科夫模型,27篇(51.92%)采用决策树模型,13篇(20.97%)采用离散事件模型。选取了9篇代表性研究,重点分析并推荐了3种模型结构。结论:精神分裂症患者的预后非常重要,应采用离散事件模型或多状态马尔科夫模型进行经济学评价,尽量避免使用短期决策树模型或三状态马尔科夫模型。OBJECTIVE In order to provide reference for pharmacoeconomic evaluation of rational selection models in the field of schizophrenia,different pharmacoeconomic models were summarized and analyzed.METHODS Literature research was used to analyze the characteristics and applicability of economic evaluation model combined with research characteristics and model structure.RESULTS 62 studies were included,of which 22(50.00%)adopted Markov model,27(51.92%)adopted decision tree model,and 13(20.97%)adopted discrete event model.We selected and analyzed nine representative studies,and then recommended three model structures.CONCLUSION The prognosis of patients with schizophrenia is very important.Discrete event model or multi-state Markov model should be used for economic evaluation,and short-term decision tree model or three-state Markov model should be avoided as far as possible.

关 键 词：精神分裂症 马尔科夫 决策树 离散事件模型 

分 类 号：R956[医药卫生—药学] R749