A review on recent advances in hydrogen peroxide electrochemical sensors for applications in cell detection  

作　　者：Yan Yu Meng Pan Jinrong Peng Danrong Hu Ying Hao Zhiyong Qian 

机构地区：[1]State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610065,China

出　　处：《Chinese Chemical Letters》2022年第9期4133-4145,共13页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Fund(NSFC,Nos.U21A20417,31930067,31525009);the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYGD18002);the support by the Fundamental Research Funds for the Central Universities

摘　　要：Hydrogen peroxide(H_(2)O_(2))is a very simple bioactive small molecule.In living organisms,H_(2)O_(2)plays an important role in intracellular signaling.It is involved in many physiological processes including cellular physiology,intracellular signaling,oxidative damage and disease progression.The tumor microenvironment enriched with H_(2)O_(2).Several electrochemical sensors have been developed and some have been put on the market.Such electrochemical sensors provide efficient,cost-effective,rapid and highly selective method of H_(2)O_(2)detection.So far,much progress has been made in the designing of materials and construction of H_(2)O_(2)sensors.This review describes the advances in the application of H_(2)O_(2)electrochemical sensors in cell detection.Enzyme-based sensors have been applied in diverse applications.In addition,recent advancements in nanotechnology have improved the development of nanozymes-based sensors.The application of noble metals,metal oxides,polymers,carbon materials and other two-dimensional materials in the design of H_(2)O_(2)sensors are discussed in detail.Moreover,the bio-stimulant types of H_(2)O_(2)sensor are summarized.Finally,the challenges and future perspectives in the application of H_(2)O_(2)electrochemical sensors in biological detection are discussed.

关 键 词：Hydrogen peroxide Electrochemical sensors Cells detection ENZYME Nanozyme 

分 类 号：Q2-33[生物学—细胞生物学] O657.1[理学—分析化学] TP212[理学—化学]